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Guidelines for Drug Stability and Stability Testing [PDF]
, 2020 Stability studies are pivotal necessities for ensuring safety, potency, and quality of drug products throughout their shelf-life. These guarantee that pharmaceutical products will remain stable and effective under the recommended storage conditions and are considered as prerequisite for approval of any pharmaceutical product.
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Supramolecularly stabilized diabetes drugs
Nature Biomedical Engineering, 2020The stabilization of co-administered insulin and pramlintide with cucurbit[7]uril-conjugated poly(ethylene glycol) in diabetic pigs enhances the overlap of their therapeutic windows.
Kim Henriksen, Morten A. Karsdal
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Antiepileptic Drugs and Mood Stability
Clinical EEG and Neuroscience, 2007This paper will discuss different definitions of the term “mood stabilizer” and highlight in detail the antiepileptic drugs carbamazepine, valproate and lamotrigine with respect to their relative strengths in stabilizing mood in bipolar patients. These drugs are heterogeneous in their mechanisms of action and in their efficacy to stabilize patients ...
Heinz Grunze +3 more
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Stability of nanosuspensions in drug delivery
Journal of Controlled Release, 2013Nanosuspensions are nanosized colloidal dispersion systems that are stabilized by surfactants and/or polymers. Because nanosizing results in the creation of new interfaces and in a positive Gibbs free energy change, nanosuspensions are thermodynamically unstable systems with a tendency toward agglomeration or crystal growth.
Yancai Wang +4 more
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ChemInform Abstract: Stability Challenges in Drug Discovery.
ChemInform, 2009AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Li Di, Edward H. Kerns
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1981
Most drugs are subject to some form of chemical decomposition, particularly when formulated as liquid dosage forms. Some of the consequences of degradation are that the aged medicinal preparation no longer has the desired pharmacological potency. It may also exhibit physical manifestations of decomposition such as the discolouration that often follows ...
A. T. Florence, D. Attwood
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Most drugs are subject to some form of chemical decomposition, particularly when formulated as liquid dosage forms. Some of the consequences of degradation are that the aged medicinal preparation no longer has the desired pharmacological potency. It may also exhibit physical manifestations of decomposition such as the discolouration that often follows ...
A. T. Florence, D. Attwood
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Theoretical and experimental studies of the stability of drug-drug interact
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016Several factors can intervene in the molecular properties and consequently in the stability of drugs. The molecular complexes formation often occur due to favor the formation of hydrogen bonds, leading the system to configuration more energy stable.
Monica F.R. Soares +4 more
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Determination of the Stability of Drugs in Plasma
Current Protocols in Pharmacology, 2002AbstractIn order for a drug to be effective, enough of the active form must reach the target to elicit the desired effect. The first‐pass effect for drugs taken orally is well known but the metabolism of drugs in plasma must also be considered during the drug discovery and development process.
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The Stability of Drug Adsorbates on Silica
Drug Development and Industrial Pharmacy, 1986Colloidal and porous silicas are used as carriers in solid, semisolid and liquid dosage forms. Adsorption of active ingredients onto their large surface areas can be used to regulate drug release or for the uniform distribution of drug in single dose units with a very low drug content.
Bernhard Kerstiens +3 more
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Role of Decomposition on Drug Stability
2020Degradation and decomposition are interchangeably used in pharmaceutical sciences and are defined as the physical or chemical processes that lead the product to decline in its intended quality characteristics, which are claimed by the manufacturer. Both physical and chemical degradation reactions affect the stability of drugs.
Muhammad Shahid Iqbal +5 more
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