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Role of Decomposition on Drug Stability
2020Degradation and decomposition are interchangeably used in pharmaceutical sciences and are defined as the physical or chemical processes that lead the product to decline in its intended quality characteristics, which are claimed by the manufacturer. Both physical and chemical degradation reactions affect the stability of drugs.
Muhammad Shahid Iqbal +5 more
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2020
This chapter evaluates drug stability, which is a vital aspect of drug development. The types of stability that will need to be examined are physical stability and chemical stability. In particular, at an early stage, it is important to determine the mechanism of any instability, the reaction kinetics involved in any instability, and the factors that ...
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This chapter evaluates drug stability, which is a vital aspect of drug development. The types of stability that will need to be examined are physical stability and chemical stability. In particular, at an early stage, it is important to determine the mechanism of any instability, the reaction kinetics involved in any instability, and the factors that ...
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Drug Stability in Biological Specimens
2020Drug stability is an important consideration that is sometimes overlooked. However, changes in drug concentration can occur after specimen collection, during storage, shipping, transport, and evidence handling. Although environmental conditions, such as temperature and exposure to light, can play an important role, drug stability is analyte dependent ...
Daniel S. Isenschmid +2 more
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Stability of Drugs with Enteral Nutrient Formulas
DICP, 1990Experiments were performed to determine the chemical stability and compatibility of cephalexin, cimetidine, diazepam, or propranolol with full-strength and half-strength Isocal, Sustacal, and Sustacal HC (Mead Johnson). The enteral nutrient formulas (ENFs) containing the solid or liquid dosage forms were stored at 24°C and samples were taken at times ...
J. G. Strom, S. W. Miller
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Drug Stability and Degradation Studies
2009Publisher Summary This chapter discusses the basic treatments of drug degradation studies, including kinetics, pathways, important factors, and typical practices for assessing both chemical and physical stability of pharmaceutical compounds. Chemical degradation reactions of pharmaceuticals follow the well-established treatments of chemical kinetics ...
Geoff G. Z. Zhang +2 more
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Effects of cyclodextrins on the chemical stability of drugs
International Journal of Pharmaceutics, 2017Cyclodextrins (CDs) are enabling pharmaceutical excipients that can enhance both solubility and stability of wide variety of drugs in aqueous solutions through formation of drug/CD inclusion complexes where apolar moieties of the drug molecules are located inside the CD cavity.
Thorsteinn Loftsson, Agnieszka Popielec
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Stabilizing Drug Molecules in Biological Samples
Therapeutic Drug Monitoring, 2005Stability is one of the basic parameters, along with accuracy, precision, selectivity, and sensitivity, for bioanalytic method validation in nonhuman and clinical pharmacology/toxicology, bioavailability (BA), bioequivalence (BE), and other studies related to the drug approval process.
Yunsheng Hsieh, Jiwen Chen
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Physical and chemical stability of drug nanoparticles
Advanced Drug Delivery Reviews, 2011As nano-sizing is becoming a more common approach for pharmaceutical product development, researchers are taking advantage of the unique inherent properties of nanoparticles for a wide variety of applications. This article reviews the physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization ...
Libo Wu, Jian Zhang, Wiwik Watanabe
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Chemical Kinetics and Drug Stability
2009In the rational design and evaluation of dosage forms for drugs, the stability of the activecomponents must be a major criterion in determining their suitability. Several forms ofinstability can lead to the rejection of a drug product. First, there may be chemicaldegradation of the active drug, leading to a substantial lowering of the quantity of ...
J. Keith Guillory, Rolland I. Poust
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Studies on lysosome stabilization by antirheumatic drugs
European Journal of Pharmacology, 1970Abstract Differential centrifugation was used to isolate a lysosome containing fraction from rat liver homogenate. The influence of cortisone, hydrocortisone, salicylate and chloroquine on the stability of the lysosomes was tested using different labilization procedures.
A. Jørgensen, John Hyttel
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