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Therapeutic delivery, 2021
Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety ...
Nisar Ul Khaliq +4 more
semanticscholar +1 more source
Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety ...
Nisar Ul Khaliq +4 more
semanticscholar +1 more source
Supramolecularly stabilized diabetes drugs
Nature Biomedical Engineering, 2020The stabilization of co-administered insulin and pramlintide with cucurbit[7]uril-conjugated poly(ethylene glycol) in diabetic pigs enhances the overlap of their therapeutic windows.
Kim, Henriksen, Morten A, Karsdal
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Recent advances in proteolytic stability for peptide, protein, and antibody drug discovery
Expert Opinion on Drug Discovery, 2021Introduction: To discover and develop a peptide, protein, or antibody into a drug requires overcoming multiple challenges to obtain desired properties. Proteolytic stability is one of the challenges and deserves a focused investigation.
Xianyin Lai, Jason X Tang, M. E. ElSayed
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, 2021
A new 1:1 drug–drug cocrystal of temozolomide and hesperetin was successfully prepared by liquid-assisted grinding, slurry conversion crystallization, and evaporation crystallization.
Jie Wang +3 more
semanticscholar +1 more source
A new 1:1 drug–drug cocrystal of temozolomide and hesperetin was successfully prepared by liquid-assisted grinding, slurry conversion crystallization, and evaporation crystallization.
Jie Wang +3 more
semanticscholar +1 more source
Stability issues and approaches to stabilised nanoparticles based drug delivery system
Journal of drug targeting (Print), 2020Nanoparticles form the fundamental building blocks for many exciting applications in various scientific disciplines due to its unique features such as large surface to mass ratio, targeting potential, ability to adsorbed and carry other compound which ...
Shaheen Sultana +7 more
semanticscholar +1 more source
Antiepileptic Drugs and Mood Stability
Clinical EEG and Neuroscience, 2007This paper will discuss different definitions of the term “mood stabilizer” and highlight in detail the antiepileptic drugs carbamazepine, valproate and lamotrigine with respect to their relative strengths in stabilizing mood in bipolar patients. These drugs are heterogeneous in their mechanisms of action and in their efficacy to stabilize patients ...
Benedikt, Amann +3 more
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Stability Challenges in Drug Discovery
Chemistry & Biodiversity, 2009AbstractStability is one of the most important properties of drug candidates. Instable compounds can lead to false positive high‐throughput screening (HTS) hits, incorrect bioassay results, erroneous structure–activity relationships (SAR), low oral bioavailability, drug withdrawal, toxic reactions from degradation products, and difficult formulation ...
Li, Di, Edward H, Kerns
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2020
This chapter evaluates drug stability, which is a vital aspect of drug development. The types of stability that will need to be examined are physical stability and chemical stability. In particular, at an early stage, it is important to determine the mechanism of any instability, the reaction kinetics involved in any instability, and the factors that ...
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This chapter evaluates drug stability, which is a vital aspect of drug development. The types of stability that will need to be examined are physical stability and chemical stability. In particular, at an early stage, it is important to determine the mechanism of any instability, the reaction kinetics involved in any instability, and the factors that ...
openaire +1 more source
2023
Stability of drug is the capacity of the pharmaceutical dosage form to maintain the chemical, physical, microbial and therapeutic properties during the time of storage and usage by the patient. Stability studies are done to determine the expiry date of products and to choose formulations and container closure techniques that are appropriate in terms of
Miss Ashu, Kavita Sapra
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Stability of drug is the capacity of the pharmaceutical dosage form to maintain the chemical, physical, microbial and therapeutic properties during the time of storage and usage by the patient. Stability studies are done to determine the expiry date of products and to choose formulations and container closure techniques that are appropriate in terms of
Miss Ashu, Kavita Sapra
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Guidelines for Drug Stability and Stability Testing
2020Stability studies are pivotal necessities for ensuring safety, potency, and quality of drug products throughout their shelf-life. These guarantee that pharmaceutical products will remain stable and effective under the recommended storage conditions and are considered as prerequisite for approval of any pharmaceutical product.
Kamran Haider +3 more
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