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Impact of Payload Hydrophobicity on the Stability of Antibody-Drug Conjugates.
Molecular Pharmaceutics, 2018In silico screening of toxin payloads typically employed in ADCs revealed a wide range of hydrophobicities and sizes as measured by log P and topological polar surface area (tPSA) values.
J. Buecheler +4 more
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[Human thrombin: drug stability and stabilization].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2007Stabilization of enzymes is a key factor when using biocatalysis in practice. Each enzyme stability depends both on the structure of its molecule and on the effect of various environmental factors, thus, one of the methods of the enzyme stability preservation is the formation of optimal macromedium.
M V, Kolodzeĭskaia +2 more
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Stability Testing: Photostability Testing of New Drug Substances and Products
Handbook of Pharmaceutical Manufacturing Formulations, Second Edition, 2021semanticscholar +1 more source
1981
Most drugs are subject to some form of chemical decomposition, particularly when formulated as liquid dosage forms. Some of the consequences of degradation are that the aged medicinal preparation no longer has the desired pharmacological potency. It may also exhibit physical manifestations of decomposition such as the discolouration that often follows ...
A. T. Florence, D. Attwood
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Most drugs are subject to some form of chemical decomposition, particularly when formulated as liquid dosage forms. Some of the consequences of degradation are that the aged medicinal preparation no longer has the desired pharmacological potency. It may also exhibit physical manifestations of decomposition such as the discolouration that often follows ...
A. T. Florence, D. Attwood
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The chemical stability of drugs plays a pivotal role in the pharmaceutical industry, impacting drug development, manufacturing, storage, and ultimately, patient safety. This abstract explores the key aspects of chemical stability, emphasizing its significance in drug formulation and quality control.
Sandeep Mukati +3 more
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Sandeep Mukati +3 more
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Drug metabolic stability in early drug discovery to develop potential lead compounds
Drug metabolism reviews (Softcover ed.), 2021S. N. Gajula +2 more
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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