Results 101 to 110 of about 6,945,281 (332)

Emerging drugs for the treatment of bladder storage dysfunction

open access: yesExpert Opinion on Emerging Drugs, 2022
Current drug treatment of lower urinary tract disorders, for example, overactive bladder syndrome and lower urinary tract symptoms associated with benign prostatic hyperplasia, is moderately effective, has a low treatment persistence and some short- and long-term adverse events.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Physical properties and solubility studies of Nifedipine-PEG 1450/HPMCAS-HF solid dispersions [PDF]

open access: yes, 2018
Low-order high-energy nifedipine (NIF) solid dispersions (SDs) were generated by melt solvent amorphization with polyethylene glycol (PEG) 1450 and hypromellose acetate succinate (HPMCAS-HF) to increase NIF solubility while achieving acceptable physical ...
Chougule, Mahavir B.   +6 more
core   +1 more source

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications [PDF]

open access: yes, 2019
Bioengineered spider silk is a biomaterial that has exquisite mechanical properties, biocompatibility, and biodegradability. Iron oxide nanoparticles can be applied for the detection and analysis of biomolecules, target drug delivery, as MRI contrast ...
Dams-Kozlowska, Hanna   +7 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Stability Dynamics of Plant-Based Extracellular Vesicles Drug Delivery

open access: yesJournal of Xenobiotics
Plant-based extracellular vesicles (PBEVs) have been recognized for their wide range of applications in drug delivery however, the extent of their medicinal applicability depends on how well they are preserved and stored.
Satyavati Rawat   +5 more
doaj   +1 more source

Technology transfer: Transportation [PDF]

open access: yes
The successful application of aerospace technology to problems related to highways and rail and rapid transit systems is described with emphasis on the use of corrosion resistant paints, fire retardant materials, and law enforcement.
Anyos, T.   +3 more
core   +1 more source

Stock Management in Hospital Pharmacy using Chance-Constrained Model Predictive Control [PDF]

open access: yes, 2016
One of the most important problems in the pharmacy department of a hospital is stock management. The clinical need for drugs must be satisfied with limited work labor while minimizing the use of economic resources.
Fernández, Isabel   +6 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Дослідження стабільності м´якого препарату для нашкірного застосування «Пробіоскін» у процесі зберігання

open access: yesAnnals of Mechnikov's Institute, 2021
Introduction. Currently, there are no means for the treatment of dermatological diseases in the domestic pharmaceutical market with the simultaneous correction and maintenance of the skin microbiome.
Alina Solovyova, Olga Kaliuzhnaia
doaj  

Home - About - Disclaimer - Privacy