Results 71 to 80 of about 6,945,281 (332)

Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]

, 2020
© The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa, Gallagher, Cathal, Isse, Libin, Mann, Sanpreet   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Knowledge of the students majoring in pharmaceutical services of the management of the household first-aid kit

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019
Background: the correct management of the household first-aid kit by the students majoring in specialties related to the use of medications is a task that needs to be included in their academic training.Objective: to identify the knowledge of the first ...
Carlos Manuel Jiménez-Martínez, Liannys Liens-Valdés, Yamila Almaguer-Laguna   +2 more
doaj  

Study on the Stability of Antioxidant Peptides from Safflower Seeds with Different Molecular Weight

Shipin gongye ke-ji, 2022
Objective: The stability of antioxidant peptide activity of safflower seed protein with different molecular weight was studied. Methods: Using shelled safflower seed meal as experimental material, antioxidant peptides were prepared by compound enzymatic ...
Xiaoyi LIU, Yuyan ZHOU, Limin GUO, Guangfei HAO   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Household Storage of Medicines and Associated Factors in Tigray Region, Northern Ethiopia. [PDF]

PLoS ONE, 2015
The presence of medicines in households is a risk factor for irrational drug use. This study aimed at investigating the prevalence and factors associated with home storage of medicines in Tigray Region, Ethiopia.A community based cross-sectional study ...
Abrham Wondimu, Fantahun Molla, Birhanu Demeke, Tadele Eticha, Admassu Assen, Solomon Abrha, Wondim Melkam   +6 more
doaj   +1 more source

81 Controlled drugs storage and improvement [PDF]

Digital poster presentations, 2020
Learning from a Serious Incident in 2018 highlighted the importance of the documentation of controlled drugs. A detailed audit was conducted in July 2019. The main areas for improvement across the trust were around documentation in the CD order book and CD register. An action plan was agreed between nursing education and pharmacy departments to support
Andrew Pearson, Hong Thoong, Rasha Shamsah, Ka Yu Yung   +3 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source