Advanced Functional Materials, EarlyView.Si3N4‐enhanced bioactive nanostructured adhesive wrap enables rapid conduit formation in wet environments, simplifying surgical procedures. Incorporated Si3N4 undergoes controlled hydrolysis within nanofibers, multi‐directionally modulating the peripheral nerve repair microenvironment for effective suture‐free repair.
Pengchao Ma +10 more
wiley +1 more source
Tumor-stroma interactions influence the response to PI3K targeted agents in preclinical models of colorectal cancer (CRC) [PDF]
, 2019 Introduction: One of the main obstacle to the successful development of therapeutic strategies remains the identification of biomarker underlying drug resistance. Recently, investigators have become more aware the role of the tumor microenvironment (TME)
Bazzichetto, Chiara
core
Defining Molecular Targets for Drug Design: Synergism Between Academia and Industry [PDF]
, 2005 Andrew C. Chan
openalex +1 more source
Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME
Advanced Functional Materials, EarlyView.A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li +10 more
wiley +1 more source
Effects of Celecoxib and Ly117018 Combination on Human Breast Cancer Cells in Vitro
Breast Cancer: Basic and Clinical Research, 2009 Activation and signalling of estrogen receptor (ER) and COX-2 represent two important pathways in breast cancer cell regulation. Activation of either pathway is associated with breast cancer cell proliferation and eventually malignant progression ...
Klaus H. Baumann +6 more
doaj
Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants [PDF]
, 2022 Denisa Bojková +7 more
openalex +1 more source
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Advanced Functional Materials, EarlyView.A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim +4 more
wiley +1 more source
Halide Perovskite Radiation Detectors: Conventional Imaging Applications and New Opportunities
Advanced Functional Materials, EarlyView.Organic–inorganic hybrid halide perovskite (OIHP) semiconductors, owing to their exceptional optoelectronic properties, are emerging as promising next‐generation integrated radiation detectors for applications in medical radiodiagnosis and healthcare monitoring.
Dou Zhao +4 more
wiley +1 more source
Design and Applications of Multi‐Frequency Programmable Metamaterials for Adaptive Stealth
Advanced Functional Materials, EarlyView.This article provides a comprehensive overview of metamaterials, including their fundamental principles, properties, synthesis techniques, and applications in stealth, as well as their challenges and future prospects. It covers topics that are more advanced than those typically discussed in existing review articles, while still being closely connected ...
Jonathan Tersur Orasugh +4 more
wiley +1 more source