Results 151 to 160 of about 3,800,890 (227)

Drug Synergism: Its Detection and Applications

The Journal of Pharmacology and Experimental Therapeutics, 2001
Two drugs that produce overtly similar effects will sometimes produce exaggerated or diminished effects when used concurrently. A quantitative assessment is necessary to distinguish these cases from simply additive action. This distinction is based on the classic pharmacologic definition of additivity that, briefly stated, means that each constituent ...
R. Tallarida
openaire   +3 more sources

Teratogenic Risks of Drug Synergism

Nature, 1964
IT is well known that the effectiveness of teratogens, measured either in incidence or in severity of resulting malformations, is frequently modified, in a plus or minus direction, by unrelated external conditions. The mechanisms by which these modifying agencies operate are largely unknown.
Ellen M. Clark, Walter Landauer
openaire   +4 more sources

The interaction index: a measure of drug synergism

Pain, 2002
Two drugs used in combination may produce enhanced or reduced effects. The degree of enhancement or reduction is measured from the interaction index (gamma), a quantity that indicates the changed potency of the combination. The index is therefore a quantitative marker for the drug combination and effect metric used.
R. Tallarida
openaire   +4 more sources

Informatics of Drug Synergism in Naturally Occurring Anticancer Agents

Recent Patents on Anti-Cancer Drug Discovery, 2011
Cancer is a multi-factorial disease resulting in uncontrolled division of body cells, with difficult and complex suppression. The main treatment strategy for this disease depends on killing of tumor cells that usually exist in the proximity of normal body cells. During the course of treatment, the healthy cells should not be affected by the toxic doses
Mohammad Reza Kazemali, Ghazaleh Ghavami, Soroush Sardari   +2 more
openaire   +4 more sources

Drug Synergism [PDF]

Science, 1958
  +5 more sources

Drug Resistance and Drug Synergism

2014
Richard B. Silverman, Mark W. Holladay
openaire   +2 more sources

Half-Sandwich Ruthenium Arene Complexes Bearing Clinically Approved Drugs as Ligands: The Importance of Metal-Drug Synergism in Metallodrug Design.

Molecular Pharmaceutics, 2023
A novel strategy in metallodrug discovery today is incorporating clinically approved drugs into metal complexes as coordinating ligands. Using this strategy, various drugs have been repurposed to prepare organometallic complexes to overcome the ...
Chezhiyan Sumithaa, M. Ganeshpandian
semanticscholar   +1 more source

Drug Synergism in Antineoplastic Chemotherapy

Advances in chemotherapy, 1964
Abraham Goldin, J. M. Venditti
openaire   +4 more sources

Predicting Drug Synergism by Means of Non-Negative Matrix Tri-Factorization

IEEE/ACM Transactions on Computational Biology & Bioinformatics, 2021
Traditional drug experiments to find synergistic drug pairs are time-consuming and expensive due to the numerous possible combinations of drugs that have to be examined.
Pietro Pinoli, G. Ceddia, S. Ceri, M. Masseroli   +3 more
semanticscholar   +1 more source

Sequential Blockage as a Theoretical Basis for Drug Synergism

Journal of Medicinal Chemistry, 1963
M. L. Black
openaire   +4 more sources