Results 271 to 280 of about 48,842 (302)

Communicating Synergism in Drug Combination Studies

Arzneimittelforschung, 2011
Isobolograms are used to identify synergistic effects of drugs given in combination. However, the traditional isobologram provides only a qualitative determination of synergism. The present report describes two procedures for quantifying the synergistic actions of drugs based on isobolographic plots.
Harlan E. Shannon, Jesse Brodkin
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Informatics of Drug Synergism in Naturally Occurring Anticancer Agents [PDF]

Recent Patents on Anti-Cancer Drug Discovery, 2011
Cancer is a multi-factorial disease resulting in uncontrolled division of body cells, with difficult and complex suppression. The main treatment strategy for this disease depends on killing of tumor cells that usually exist in the proximity of normal body cells. During the course of treatment, the healthy cells should not be affected by the toxic doses
Ghavami, Ghazaleh, Kazemali, Mohammad R, Sardari, Soroush   +2 more
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Synergism in Drug Treatment of Familial Hypercholesterolemia [PDF]

, 1980
The monogenic disorder familial hypercholesterolemia (FH) is associated with a high risk of premature coronary arteriosclerosis, largely attributable to a 2-3 fold increase in levels of low density lipoproteins (LDL) in serum. Heretofore, no regimen of drug therapy or surgical intervention has been reported which is capable of lowering levels of low ...
M. J. Malloy, J. P. Kane, P Tun, R. J. Havel   +3 more
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A Fatality Due to Drug Synergism

Medicine, Science and the Law, 1982
Thioridazine is a phenothiazine tranquillizer with specificity for psychotherapeutic action. It is well tolerated but will induce changes in myocardial repolarization which are further aggravated in the presence of low blood potassium levels. Fatalities due to overdosage of thioridazine are rare and those associated with therapeutic dosage and cross ...
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Synergism between Histamine, Antihistamines, and Hypnotic Drugs†

Journal of the American Pharmaceutical Association (Scientific ed.), 1952
The synergism between antihistamines and the barbiturate Evipal was studied in mice. Similar synergism was found between histamine and barbiturates and between antihistamines and ether. The possible clinical usefulness of these findings is discussed. Thephorin, in mice, shows a synergistic effect with barbiturates or ether similar to that of Benadryl ...
Clara M. Ambrus, Joseph W.E. Harrisson, Julian L. Ambrus, C.E. Moser, Charles A. Leonard   +4 more
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A Test for Synergism Between Two Drugs

Applied Statistics, 1976
A likelihood ratio test is devised to detect the presence of synergism between two drugs which have similar actions. An example is given.
S. C. Darby, M. J. Ellis
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The interaction index: a measure of drug synergism

Pain, 2002
Two drugs used in combination may produce enhanced or reduced effects. The degree of enhancement or reduction is measured from the interaction index (gamma), a quantity that indicates the changed potency of the combination. The index is therefore a quantitative marker for the drug combination and effect metric used.
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Synergism of Three Antimicrobial Drugs

Nature, 1966
COMBINED therapy with two or more antibacterial drugs may be useful in the treatment of an individual case, and in discouraging the development of resistance1. A formula was previously presented which could be used in evaluating the combined effect of two drugs2.
Deborah Kaplan, Walter Koch
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Abstract B17: Identification of drugs that synergize with immunotherapies

Cancer Immunology Research, 2020
Abstract Introduction: Immune checkpoint blockers (ICB) revitalize the immune system against cancer cells and have led to breakthroughs in cancer treatment and unprecedented survival benefits. However, they are ineffective in the majority of advanced cancer patients.
Keith T. Flaherty, Shirley Liu, Avinash Das Sahu, Jan Klomp, Arthur Oubrie, Xiaoman Wang   +5 more
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Drug Synergism: Its Detection and Applications

The Journal of Pharmacology and Experimental Therapeutics, 2001
Two drugs that produce overtly similar effects will sometimes produce exaggerated or diminished effects when used concurrently. A quantitative assessment is necessary to distinguish these cases from simply additive action. This distinction is based on the classic pharmacologic definition of additivity that, briefly stated, means that each constituent ...
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