Results 271 to 280 of about 82,521 (353)

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

Anticholinergic and sedative medications use among community dwelling older adults: risk for polypharmacy and poor physical function. [PDF]

BMC Geriatr
Selcuk A, Atmis V, Sen S, Gemci E, Yurumez B, Yalcin A, Bozkir A, Aras S, Varli M.   +8 more
europepmc   +1 more source

Porous Coatings by Vapor Sublimation and Deposition for Molecular Channeling and Filtration in an Interstitial Fluid Microfiltration Device

Advanced Healthcare Materials, EarlyView.
A vapor‐based porous coating applied within nitinol tubes demonstrated complete suppression of cellular and tissue ingrowth, overcoming a major limitation of implantable interstitial fluid collection devices. Molecular channeling and diffusion are analyzed with probe molecules, showing reliable transport in vitro and in vivo. The coating also achieved >
Yu‐Ming Chang, Chi‐Yu Huang, Yi‐Jia Ke, Yi‐Wei Lin, Yen‐Hui Chan, Ying‐Chang Lu, Yu‐Chih Chiang, Chen‐Chi Wu, Hsien‐Yeh Chen   +8 more
wiley   +1 more source

Dual-site spatiotemporal and simultaneous inhibition on PIN1 via arsenic-retinoic albumin nanoparticles enables synergistic oncotherapy. [PDF]

J Nanobiotechnology
Yang D, Wang J, Liu R, Chen J, Wen H, Li Y, Lu B, Guo Z, Cui D, Jia L, Dong H.   +10 more
europepmc   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Combination of the First-in-Class Imipridone ONC201 and Standard Anticancer Therapies as a Rational Approach for Therapeutic Benefit. [PDF]

Curr Issues Mol Biol
Shenoy B, Mandani M, Chintamaneni M, Manohar SM.   +3 more
europepmc   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Silvestrol inhibits nasopharyngeal carcinoma cells and synergizes with CX-5461: Insights from a proteomics study. [PDF]

Mol Clin Oncol
Daker M, Ahmad M, Khoo AS, Tan LP, Chin SF, Hwang SS, Neilsen PM.   +6 more
europepmc   +1 more source

Increased cyclosporine uptake by cells pretreated with FK506 and evidence for binding of both drugs to a common intracellular protein [PDF]

, 1989
Diven, WF, Sanghvi, A, Starzl, T, Todo, S, Warty, VS   +4 more
core  

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source