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A Fatality Due to Drug Synergism
Medicine, Science and the Law, 1982Thioridazine is a phenothiazine tranquillizer with specificity for psychotherapeutic action. It is well tolerated but will induce changes in myocardial repolarization which are further aggravated in the presence of low blood potassium levels. Fatalities due to overdosage of thioridazine are rare and those associated with therapeutic dosage and cross ...
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Synergism between Histamine, Antihistamines, and Hypnotic Drugs†
Journal of the American Pharmaceutical Association (Scientific ed.), 1952The synergism between antihistamines and the barbiturate Evipal was studied in mice. Similar synergism was found between histamine and barbiturates and between antihistamines and ether. The possible clinical usefulness of these findings is discussed. Thephorin, in mice, shows a synergistic effect with barbiturates or ether similar to that of Benadryl ...
Clara M. Ambrus +4 more
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A Test for Synergism Between Two Drugs
Applied Statistics, 1976A likelihood ratio test is devised to detect the presence of synergism between two drugs which have similar actions. An example is given.
S. C. Darby, M. J. Ellis
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Molecular Pharmaceutics, 2018
Cancer therapies based on the combinations of different drugs and/or treatment modalities are emerging as important strategies for increasing efficacy and cure, decreasing unwanted toxicity, and overcoming drug resistance, provided that optimized drug ...
Elisa Gaio +6 more
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Cancer therapies based on the combinations of different drugs and/or treatment modalities are emerging as important strategies for increasing efficacy and cure, decreasing unwanted toxicity, and overcoming drug resistance, provided that optimized drug ...
Elisa Gaio +6 more
semanticscholar +1 more source
Synergism of Three Antimicrobial Drugs
Nature, 1966COMBINED therapy with two or more antibacterial drugs may be useful in the treatment of an individual case, and in discouraging the development of resistance1. A formula was previously presented which could be used in evaluating the combined effect of two drugs2.
Deborah Kaplan, Walter Koch
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Abstract B17: Identification of drugs that synergize with immunotherapies
Cancer Immunology Research, 2020Abstract Introduction: Immune checkpoint blockers (ICB) revitalize the immune system against cancer cells and have led to breakthroughs in cancer treatment and unprecedented survival benefits. However, they are ineffective in the majority of advanced cancer patients.
Keith T. Flaherty +5 more
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Drug Synergism and Dose-Effect Data Analysis
, 2000Combinations of Chemicals Dose-Response Analysis Linear Regression: A Further Discussion Calculations for Combination Drug Analysis. The Composite Additive Curve Quantal Dose-Response Data: Probit and Logit Analysis Analysis of Drug Combinations over a ...
R. Tallarida
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Science, 1979
Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a synergistic effect on the number of cells killed in culture.
E. Cadman, R. Heimer, L. Davis
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Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a synergistic effect on the number of cells killed in culture.
E. Cadman, R. Heimer, L. Davis
semanticscholar +1 more source
Search for a Synergism with Different Drugs in the Field of Antiviral Chemotherapy
Chemotherapy, 1971Additional findings about the synergism between Rec. 15/0209 and Amantadine are reported. While it is clearly demonstrable in embryonated and de-embryonated chicken eggs by measuring both virus titer and virus RNA synthesis of CAM suspensions, the results are much less constant in the embryonated eggs by measuring HA in the allantoic fluids and over ...
P. Altucci +4 more
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