Results 341 to 350 of about 3,780,548 (370)
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Quantitative Aspects of Drug Antagonism and of Drug Synergism
1937It was shown in the last chapter that, in populations of animals, changes in sensitivity to drugs can be produced by a wide variety of causes, and that in some cases variations in sensitivity occur for which the causes are unknown. It seems justifiable to assume that if the condition of organisms is altered by the administration of one drug, then this ...
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Synergism between staurosporine and drugs inducing endoplasmic reticulum stress
Biochemical Pharmacology, 2006Drugs causing endoplasmic reticulum or mitochondrial dysfunction may trigger apoptosis in eukaryotic cells. The thiol reagent dithiothreitol (DTT) belongs to the first group whereas the protein kinases inhibitor staurosporine acts on mitochondria. Since the endoplasmic reticulum and the mitochondrial pathways of apoptosis may converge in common steps ...
CUSINATO, FEDERICO +3 more
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Absence of antimycobacterial synergism between garlic extract and antituberculosis drugs
Diagnostic Microbiology and Infectious Disease, 1987Garlic extract inhibited the growth of four strains of Mycobacterium tuberculosis, three strains of Mycobacterium avium-intracellulare, and three strains of Mycobacterium kansasii in concentrations ranging from 0.98 mg/ml to 2.94 mg/ml. Synergism could not be demonstrated when garlic extract was added to various concentrations of four commonly used ...
Edward C. Delaha +2 more
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Evaluation of the effect of cavitation activity on drug-ultrasound synergisms
1993 Proceedings IEEE Ultrasonics Symposium, 1993The authors investigated the effect of therapeutic ultrasound (1 MHz; 0.5-4 W/cm2) on mammalian cells grown in culture in an exposure system that allowed measurement of sub-harmonic generation. They were able to correlate subharmonic generation in the cell samples, a signature of acoustic cavitation, with cell lysis.
R.J. Jeffers +5 more
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Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane
Molecular and Cellular Endocrinology, 201990 kDa heat shock proteins (Hsp90) act as protein chaperones and play a role in modulating endoplasmic reticulum (ER) stress. Hsp90 inhibitors are under clinical investigation as cancer treatment. Mitotane therapy of adrenocortical carcinoma (ACC) has been shown to act through lipid-induced ER-stress. To explore the potential of Hsp90 inhibitors in ACC
Silviu Sbiera +5 more
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Synergizing drug repurposing and target identification for neurodegenerative diseases
Despite dedicated research efforts, the absence of disease-curing remedies for neurodegenerative diseases (NDDs) continues to jeopardize human society and stands as a challenge. Drug repurposing is an attempt to find new functionality of existing drugs and take it as an opportunity to discourse the clinically unmet need to treat neurodegeneration ...Mehar Sahu +6 more
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Synergism with GABAergic drugs in refractory epilepsy
The Lancet, 1994MartinJ. Brodie, John Paul Leach
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