Results 201 to 210 of about 881,158 (314)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Drug targeting of aminopeptidases: importance of deploying a right metal cofactor. [PDF]

Biophys Rev
Bhat SY.
europepmc   +1 more source

Novel paradigms in KRAS targeting: Unveiling strategies to combat drug resistance

Xiyuan Luo, Feihan Zhou, Yuemeng Tang, Xiaohong Liu, Ran Xiao, Minzhi Gu, Jialu Bai, Dong Jiang, Gang Yang, Lei You, Yupei Zhao   +10 more
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics. [PDF]

Medicina (Kaunas)
Singh M, Negi R, Alka, Vinayagam R, Kang SG, Shukla P.   +5 more
europepmc   +1 more source

Targeted Drug Delivery System in Nanorobotics

Samanthula Likhitha*1, Venkaiahppalaswamy B.2, Bandaru Santhoshi Lakshmi Bhavana3, Gunnam Sai Saranya3, Korukonda Sree Divya3, Madada Sowjanya3, Vaddireddy Yema Durga Anjali Kumari3, Vantari Vidya Sagar3
openalex   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Harnessing Porphyrin Accumulation in Liver Cancer: Combining Genomic Data and Drug Targeting. [PDF]

Biomolecules
Adapa SR, Meshram P, Sami A, Jiang RHY.
europepmc   +1 more source

A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs

, 2019
Lulu Zhao, Xinyu Yuan, Jubo Wang, Yifan Feng, Fei Ji, Zhiyu Li, Jinlei Bian   +6 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source