Results 221 to 230 of about 1,512,902 (358)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Exploring the multifaceted roles of resuscitation-promoting factors in tuberculosis: Implications for diagnosis, vaccine development, and drug targeting. [PDF]

Biotechnol Rep (Amst)
Tanriver G, Ali Khan S, Góra A, Chegou NN, Mahmoudi S.   +4 more
europepmc   +1 more source

Evaluation of a Novel PLGA-HA-Based Drug Delivery System Targeting the cell cycle and PI3K/AKT/mTOR Pathway in HCT116 Colorectal Carcinoma Cells with Differing P53 Statuses

Dr Abdulla Saleh Abdulla Hassan, Goran Othman, Esmaeil Babaei   +2 more
openalex   +1 more source

Inhibition of Bacterial Virulence: Drug‐Like Molecules Targeting the Salmonella enterica PhoP Response Regulator [PDF]

, 2012
Yat Tang, Rong Gao, James J. Havranek, Eduardo A. Groisman, Ann Stock, Garland R. Marshall   +5 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens. [PDF]

Nat Commun
Tran SL, Lebreuilly L, Cormontagne D, Samson S, Tô TB, Stosskopf M, Dervyn R, Grießhammer A, de la Cuesta-Zuluaga J, Maier L, Naas T, Mura S, Rognan D, Nicolas J, André G, Ramarao N.   +15 more
europepmc   +1 more source

Nanofibers in Ocular Drug Targeting and Tissue Engineering: Their Importance, Advantages, Advances, and Future Perspectives. [PDF]

Pharmaceutics, 2023
Uzel E, Durgun ME, Esentürk-Güzel İ, Güngör S, Özsoy Y.   +4 more
europepmc   +1 more source

Multilayered Nanoarchitectonicsof Poly(ethylene glycol)Nanoparticles with Tunable Stiffness Modulate Bio–Nano Interactionsand Targeted Drug Delivery

Mengqi Li (2608237), Zhiliang Gao (298188), Huiyuan Lv (11897534), Kanaparedu P. C. Sekhar (9929669), Aixin Song (1404538), Xinyi Jiang (1976353), Jingcheng Hao (1404541), Jiwei Cui (1278657)   +7 more
openalex   +1 more source

Using Bioinformatics to Identify Novel Druggable Targets for Retinal Neovascularisation Causing Loss of Vision: Transforming Growth Factor Beta-Activated Kinase 1 (TAK1)

, 2018
G. J. Dusting, Jiang-Hui Wang, Damien Ling, Leilei Tu, Moeen Riaz, Peter van Wijngaarden, Guei‐Sheung Liu   +6 more
openalex   +2 more sources

No end in sight for telomerase-targeted cancer drugs [PDF]

, 2013
Sarah Williams
openalex   +1 more source