Results 101 to 110 of about 5,501,792 (312)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Can Tenants in Privately Owned Apartments Be Drug Tested? [PDF]

This article is the winner of the Apartments manuscript prize [sponsored by the National Multi Housing Council (NMHC)] presented at the 2001 American Real Estate Society Annual Meeting.
Robert J. Aalberts
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluation of antioxidant co-therapy for polymyxin B-associated nephrotoxicity and mortality: a real-World retrospective cohort study

Journal of Pharmaceutical Policy and Practice
Background Polymyxin B is increasingly used to treat infections caused by multidrug-resistant gram-negative bacteria; however, its widespread clinical use is hindered by the high incidence of nephrotoxicity.
Jianting Qi, Zhao Yin, Yali Peng, Feibiao Zhang, Yanli Li, Xudong Xia, Xuedong Jia   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Identification of AB‐FUBINACA metabolites in authentic urine samples suitable as urinary markers of drug intake using liquid chromatography quadrupole tandem time of flight mass spectrometry

, 2016
Synthetic cannabinoids are a group of psychoactive drugs presently widespread among drug users in Europe. Analytical methods to measure these compounds in urine are in demand as urine is a preferred matrix for drug testing.
Henrik Gréen, Martin Josefsson, Vikingsson, Svante,, Svante Vikingsson, Gréen, Henrik,, Brinkhagen, Linda,, Shahzabe Mukhtar, Josefsson, Martin,, Mukhtar, Shahzabe,, Linda Brinkhagen   +9 more
core   +1 more source

Study on the Degradation Products of Zearalenone Using UHPLC-Q-TOF-MS

Liang you shipin ke-ji
The study employed UHPLC-Q-TOF-MS to analyze zearalenone (ZEN) in maize processed by high-temperature and high-pressure extrusion. The degradation efficiency and degradation products were investigated.
REN Ling-yun, YANG Lin-lin, JIANG Yuan-yuan, DONG Bin, WANG Jun, XUE Xia, WANG Fei-fei, ZHANG Jin-na   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Random drug testing of schoolchildren: a shot in the arm or a shot in the foot for drug prevention? [PDF]

, 2005
The idea of randomly drug-testing UK schoolchildren to see if they have used illegal drugs has received supportive comments recently from both the Prime Minister and the Leader of the Opposition.
McKeganey, Neil
core  

Workplace drug testing in italy: Findings about second-stage testing

, 2014
Workplace Drug Testing (WDT) in Italy includes two levels of monitoring: a first stage concerning drug testing on urine samples and a second involving both urine and hair analysis.
Luca Morini, Claudia Vignali, MORINI, LUCA, San Bartolomeo P, Angelo Groppi, GROPPI, ANGELO, Cristiana Stramesi, VIGNALI, CLAUDIA MARIA, STRAMESI, CRISTIANA, Paolo San Bartolomeo   +9 more
core   +1 more source