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Ohio BWC Drug-Free EZ Program : technical assistance manual : reference/resource guide

, 2002
Title from title screen (viewed Sept. 24, 2004).; "BWC-7648 (Rev. 7/18/2002)"--Screen 87 (i.e. p. 1 of form: Progress report, Drug-Free Workplace/Drug-Free EZ Program).; Electronic text (pdf, 89 p.).; Harvested from the web on 9/24 ...
Drug-Free EZ Program (Ohio. Bureau of Workers' Compensation)
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Genomic comparison reveals single-nucleotide polymorphic sites and attenuation-associated site combinations specific to Chinese live attenuated varicella-zoster virus vaccines

Human Vaccines & Immunotherapeutics
The live-attenuated varicella-zoster virus (VZV) vaccine, mainly based on the Oka strain, is essential for the prevention and control of chickenpox (varicella).
Yuchan Zhang, Xuhua Duan, Yuanyuan Cai, Mingren Wang, Ziqiang Wang, Minghui Song, Tianyi Qiu, Xuanyi Wang, Hong Shao   +8 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Quantitative detection of chicken and duck derivatives in pork products based on digital PCR technique

Shipin yu jixie
ObjectiveTo establish a polymerase chain reaction (PCR) quantitative detection method for chicken and duck adulteration in pork.MethodsPrimers and probes are designed based on single-copy genes specific to porcine, duck, and chicken.
YANG Xiaoli, XIN Le, CUI Ying, LI Hongduo, YOU Yaning   +4 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Multi-strategy ugt mining, modification and glycosyl donor synthesis facilitate the production of triterpenoid saponins

Frontiers in Plant Science
Triterpenoid saponins are a class of plant secondary metabolites with significant biological activities and are widely used in the pharmaceutical and nutritional supplement industries.
Lin Hao, Yu Liu, Guiru Dong, Jingyan Liu, Kai Qiu, Xiaopeng Li, Yanan Qiao   +6 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

72 Gardaí trained to use drug test.

, 2017
Legislation has come into effect allowing gardaí to carry out mandatory roadside drug testing on motorists for cannabis, cocaine, opiates and benzodiazepines.........
Fegan, Joyce
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Metabolomics and polysaccharide fingerprinting reveal compositional differences between cultivated Fritillaria bulbs and flower by-products

Food Chemistry: X
Although Fritillariae Cirrhosae Bulbus (FCB) is used in food-related product contexts and local botanical-infusion practices, co-produced flowers remain underutilized and poorly characterized.
Zhao Geng, Yijie Ren, Zhen Hu, Chengjun He, Donglin Gu, Zhichun Zhang, Yan Gou, Jingzhe Pu, Yazhong Zhang, Lei Yang, Jincai Lu   +10 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source