Results 111 to 120 of about 10,148,101 (391)

Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve? [PDF]

, 2012
In the early 1990s, within three years of cloning of endothelin receptors, orally active endothelin receptor antagonists (ERAs) were tested in humans and the first clinical trial of ERA therapy in humans was published in 1995.
Barton, Matthias, Cleland, John G., Kohan, Donald E., Rubin, Lewis J., Theodorescu, Dan   +4 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation

Scientific Reports, 2020
In clinical trials with early Alzheimer’s patients, administration of anti-amyloid antibodies reduced amyloid deposits, suggesting that immunotherapies may be promising disease-modifying interventions against Alzheimer’s disease (AD).
Thore Hettmann, Stephen D. Gillies, Martin Kleinschmidt, Anke Piechotta, Koki Makioka, Cynthia A. Lemere, Stephan Schilling, Jens-Ulrich Rahfeld, Inge Lues   +8 more
doaj   +1 more source

Drug interaction study in hospitalized hepatic cirrhosis patient in Dr.Ramelan navy hospital [PDF]

, 2009
Cirrhotic liver lead to some changes in pathophysiology such as reduction in liver blood flow, decrease some metabolic and synthetic function of the liver. Also there is a change in endothelial lining from hepatic sinusoid.
., Widyati, Bagijo, Hary, Hubeis, A. Aziz., Lorensia, Amelia   +3 more
core  

Life After Losing an Adult Child to a Drug Overdose: A Kawa Perspective [PDF]

, 2019
Background: Limited research is available to occupational therapy practitioners focusing on parents’ abilities to cope with the loss of an adult child to a drug overdose.
De Brun, Jessica Nicole, Javaherian-Dysinger, Heather, Kugel, Julie D, Weis, Aaron   +3 more
core   +2 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Roles of Lipolytic enzymes in Mycobacterium tuberculosis pathogenesis

Frontiers in Microbiology
Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that can endure for long periods in an infected patient, without causing disease. There are a number of virulence factors that increase its ability to invade the host.
Hong Lin, Jiayin Xing, Hui Wang, Shuxian Wang, Ren Fang, Xiaotian Li, Zhaoli Li, Ningning Song   +7 more
doaj   +1 more source

A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: An interim report [PDF]

, 1998
Background. Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. Methods.
Demetris, J, Dodson, F, Fung, JJ, Hamad, I, Jain, AB, Kramer, D, Mcmichael, J, Rakela, J, Starzl, TE   +8 more
core   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Nine months to progression using fourth-line liposomally encapsulated paclitaxel against hepatocellular carcinoma [PDF]

, 2008
Background: Hepatocellular carcinoma (HCC) is the third most common cause of cancer deaths. Difficulties to diagnose HCC at early stages remain the major obstacle to curative (surgical) therapy. Therapy in advanced stages has to be considered palliative.
Bartelheim, Kerstin, Christopeit, Maximilian, Forstpointner, Roswitha, Kuehnbach, Robert, Lenz, Georg, Naujoks, Kurt, Schalhorn, Andreas   +6 more
core   +1 more source