Results 131 to 140 of about 5,954,250 (317)

Therapeutic Drug Monitoring of Elexacaftor, Tezacaftor, and Ivacaftor in Adult People with Cystic Fibrosis

Background/Objectives: Elexacaftor, tezacaftor, and ivacaftor (ETI) have significantly improved lung function in people with cystic fibrosis (pwCF). Despite exceptional improvements in most cases, treatment-related inter-subject variability and drug ...
Melanie Goetschke, Michael Vogeser, Uwe Liebchen, Sarah Sieber, Katharina Habler, Juergen Behr, Christina Shad, Olaf Sommerburg, Magdalena Breuling, Johanna Kastenberger, Susanne Naehrig, Alexandra Katharina Kunzelmann, Michael Paal   +12 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Trends in problematic gambling among school-aged adolescents based on three Spanish nationwide population-based studies (2018–2023): a gender-based analysis of risk and protective factors

Scientific Reports
This observational study investigated the prevalence and associated factors of problematic gambling (PG) among adolescents aged 14 to 18 years old who reported gambling in the past 12 months, using data from three Spanish Nationwide Population-Based ...
Domingo Palacios-Ceña, Lidiane Lima Florencio, María Palacios-Ceña, Valentín Hernández-Barrera, Isabel Jiménez-Trujillo, Carmen Gallardo-Pino, Pilar Carrasco-Garrido   +6 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Treatment - Drug Therapy

Journal of Atherosclerosis and Thrombosis, 2008
Teramoto, Tamio, Sasaki, Jun, Ueshima, Hirotsugu, Egusa, Genshi, Kinoshita, Makoto, Shimamoto, Kazuaki, Daida, Hiroyuki, Biro, Sadatoshi, Hirobe, Kazuhiko, Funahashi, Tohru, Yokote, Koutaro, Yokode, Masayuki   +11 more
openaire   +3 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Nirmatrelvir/ritonavir: real world drug-drug interaction management experience [PDF]

Background In the UK, a regional vertical system for the delivery of COVID-19 medicines has been in place. This enabled centralization of expertise in risk stratification of patients, and in understanding and mitigating drug–drug interactions.
Boffito, Marta, Davies, Gary, Ng, Megan, Hughes, Stephen, Mughal, Nabeela, Karagozlu, Zekiye, Vargas Zhang, Adrian, Bukhari, Shahid, Moore, Luke SP   +8 more
core   +1 more source

A comprehensive method on black-legged tick larvae and nymph feeding on mice to study Lyme disease transmission and acquisition

Frontiers in Microbiology
Tick-borne diseases are a growing public health concern in the United States, with cases rising steadily each year. Lyme borreliosis, or Lyme disease, remains the most prevalent, affecting approximately 476,000 individuals annually.
Aaron Scholl, Bingjie Li, John Dennis, Sandip De   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source