Results 111 to 120 of about 5,954,250 (317)

Characterization and efficacy against carbapenem-resistant Acinetobacter baumannii of a novel Friunavirus phage from sewage

Frontiers in Cellular and Infection Microbiology
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a new threat in recent years, owing to its rapidly increasing resistance to antibiotics and new effective therapies are needed to combat this pathogen.
Zhitao Wang, Xue Yang, Hui Wang, Shuxian Wang, Ren Fang, Xiaotian Li, Jiayin Xing, Qianqian Wu, Zhaoli Li, Ningning Song   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ohio BWC Drug-Free EZ Program : technical assistance manual : reference/resource guide

, 2002
Title from title screen (viewed Sept. 24, 2004).; "BWC-7648 (Rev. 7/18/2002)"--Screen 87 (i.e. p. 1 of form: Progress report, Drug-Free Workplace/Drug-Free EZ Program).; Electronic text (pdf, 89 p.).; Harvested from the web on 9/24 ...
Drug-Free EZ Program (Ohio. Bureau of Workers' Compensation)
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Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

In recent years, the field of drug delivery has witnessed remarkable progress, driven by the quest for more effective and precise therapeutic interventions.
Jee-Woong Park, Dongsik Park, Su Jin Lee
core   +1 more source

Effectiveness Bank Bulletin [Behavioral couples therapy]. [PDF]

, 2013
Behavioral couples therapy for substance abusers: where do we go from here? Klostermann K., Kelley M.L., Mignone T. et al. Substance Use & Misuse: 2011, 46, p. 1502–1509. Problem drinkers and drug users in a persisting if distressed relationship with

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Hypoxia-responsive drug-drug conjugated nanoparticles for breast cancer synergistic therapy

, 2016
In order to eliminate tumors, it is necessary to kill differentiated cancer cells, cancer stem cells (CSCs) and the "vascular niche" synergistically.
Zhang, Miao, Zhang, Xin, Li, Yan, Tang, Qunwei, Zhang, Ruilong   +4 more
core   +1 more source

Integrated computational and experimental immunoengineering of adeno-associated virus capsid T cell epitopes in mice

Nature Communications
Adeno-associated virus (AAV) vectors are widely used in gene therapy, but their immunogenicity remains a significant challenge, limiting long-term efficacy and the feasibility of repeated administration. In this study, we combine computational prediction
Sojin Bing, Arya Eskandarian, Sean Smith, Abdul Mohin Sajib, Stephanee Warrington, Sima Saleh, Susana S Najera, Rebecca J. D’Esposito, Luis Santana-Quintero, Ronit Mazor   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Progress of anti-tuberculosis drug targets and novel therapeutic strategies

Frontiers in Microbiology
Tuberculosis, a chronic infectious disease caused by Mycobacterium tuberculosis complex, has re-emerged as the leading cause of death worldwide as a single infectious agent.
Yang Zhang, Ruiying Wu, Mingrui Sun, Xiaotian Li, Ren Fang, Jiayin Xing, Zhaoli Li, Yurong Wen, Ningning Song   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source