Results 211 to 220 of about 5,099,978 (377)

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus [PDF]

, 2011
Ian M. Overton, Shirley Graham, Katherine A. Gould, Jason Hinds, Catherine H. Botting, Sally L. Shirran, Geoffrey J. Barton, Peter J. Coote   +7 more
openalex   +1 more source

Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole‐size spatially fractionated radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose/objective We propose a novel lattice deployment for spatially fractionated radiotherapy (SFRT) treatments. In this approach, a larger diameter high‐dose sphere is centrally placed in the bulky tumor mass and surrounded by smaller diameter high‐dose spheres.
Joshua Misa, William St. Clair, Damodar Pokhrel   +2 more
wiley   +1 more source

Design specification of Partial Ordering Continual Reassessment Method based on consistency conditions [PDF]

arXiv
The study of combinations of drugs/drug-schedules gained increasing attention in various therapeutic areas recently. In oncology, the aim of phase I combination clinical trial is to find the maximum tolerated combination (MTC). Many innovative designs were proposed, among which the Partial Ordering Continual Reassessment Method (POCRM) is increasingly ...
arxiv  

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism [PDF]

, 2011
Kristin N. Adams, Kevin K. Takaki, Lynn Connolly, Heather Wiedenhoft, Kathryn Winglee, Olivier Humbert, Paul H. Edelstein, Christine L. Cosma, Lalita Ramakrishnan   +8 more
openalex   +1 more source

Management and Outcomes in Confirmed or Suspected Acute Symptomatic Seizure: Role of Structured Outpatient Care

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Post‐discharge management and outcomes of acute symptomatic seizures (ASyS) remain underexplored. We analyzed post‐discharge ASM management and outcomes in ASyS patients undergoing continuous EEG (cEEG), including the role of outpatient care through a post‐acute symptomatic seizure (PASS) clinic. Methods We performed a single‐center,
Vineet Punia, MarieElena Byrnes, Nicolas R. Thompson, Neishay Ayub, Clio Rubinos, Sahar Zafar, Adithya Sivaraju, Zhong Ying, Jessica R. Fesler, Stephen Hantus, Post‐Acute Symptomatic Seizure Investigation and Outcomes Network (PASSION) investigators   +10 more
wiley   +1 more source

Ensemble optimal control for managing drug resistance in cancer therapies [PDF]

arXiv
In this paper, we explore the application of ensemble optimal control to derive enhanced strategies for pharmacological cancer treatment. In particular, we focus on moving beyond the classical clinical approach of giving the patient the maximal tolerated drug dose (MTD), which does not properly exploit the fight among sensitive and resistant cells for ...
arxiv  

Examination on tolerance and pharmacokinetics in normal person in new oligosaccharide system antimicrobial drug SCH27899 single administration.

, 1999
Masayuki Niwa
openalex   +2 more sources

A possible mechanism of drug tolerance in mycobacteria [PDF]

, 2011
S V Ranson
openalex   +1 more source

Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling, Johannes P. van Dijk, Prisca R. Bauer, Roland D. Thijs, Josemir W. Sander, Machiel Zwarts, Gerhard H. Visser   +6 more
wiley   +1 more source

Analysis of Tolerance and Behavioral/Physical Dependence during Chronic CB₁Agonist Treatment: Effects of CB₁Agonists, Antagonists, and Noncannabinoid Drugs [PDF]

, 2012
Rajeev I. Desai, Ganesh A. Thakur, Kiran Vemuri, Shama Bajaj, Alexandros Makriyannis, Jack Bergman   +5 more
openalex   +1 more source