Results 231 to 240 of about 132,064 (306)

The Impact of Drug Trafficking on Deforestation and Air Pollution in Mexico

Andres Nizri
openalex   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Comparison of Digital Forensic Tools for Drug Trafficking Cases on Instagram Messenger using NIST Method

Muhammad Fahmi Mubarok Nahdli, Imam Riadi, Muhammad Kunta Biddinika   +2 more
openalex   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Focused ultrasound-enhanced cell therapy for brain tumors: Summary of roundtable discussions. [PDF]

Neurooncol Adv
Padilla F, Arvanitis C, Bollard CM, Gallus M, De Groot J, Klein RS, Ransohoff RM, Sonabend AM, Okada H.   +8 more
europepmc   +1 more source

Forensic characteristics of the prevalence, subject and method of illegal drug trafficking committed using the Internet

A. E. Grigorieva, A. A. Antipina
openalex   +2 more sources

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

From oversight to insight: the curious case of the endothelial insulin receptor. [PDF]

Blood Vessel Thromb Hemost
Rajala R.
europepmc   +1 more source

Kaempferol inhibits <i>Chlamydia psittaci</i> proliferation by blocking lipid transport and RB-EB differentiation. [PDF]

Front Microbiol
Lin Y, Jiang Y, Zhang S, Zhang Z, Liu S, Lin J, Chen X, Zhang Y, Yu Y, Wei W, OuYang X, Huang X, Song Y, Jiao J.   +13 more
europepmc   +1 more source