Results 211 to 220 of about 345,035 (349)

Human Trafficking in the Drug Trade: Lessons for Attorneys from the Mary Jane Veloso Case

, 2016
Felicity Gerry
openalex  

Criminal Governance and Structural Facilitation of Transnational Drug Trafficking in Latin America (2006–2025): A Comparative Criminological Analysis

Sergio Pommier Gallo
openalex   +1 more source

Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection. [PDF]

eGastroenterology
Ring JJ, Schlienkamp S, Goussain Darido ML, Zhang X, Pinto Veiga O, Haase JA, Richter E, Gömer A, Fu RM, Dao Thi VL, Ulrich RG, Klöhn M, Todt D, Bader V, Winklhofer KF, Kinast V, Neyts J, Kaptein SJF, Steinmann E, Brüggemann Y.   +19 more
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants. [PDF]

JCI Insight
Moster KRC, Vanoye CG, Chang-Gonzalez AC, Romaine IM, Stefanski KM, Wilkinson MC, Bauer JA, Hasaka TP, Days EL, Desai RR, Butcher KR, Sulikowski GA, Waterson AG, Meiler J, Ledwitch KV, George AL, Sanders CR.   +16 more
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Membrane Curvature and Cancer: Mechanisms, Implications, and Therapeutic Perspectives. [PDF]

Cancers (Basel)
Damalas A, Kyriazis ID, Tutkus M, Angelidis C, Trachana V.   +4 more
europepmc   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Drug trafficking, gang fights and serial homicides: biography of a young man in conflict with the law

, 2014
Fialho, Lia Machado Fiuza, Charliton José dos Santos Machado, José Albio Moreira de Sales   +2 more
openalex   +1 more source

Modulation of NMDA Receptor and TRPM4 Activity in Hippocampal Neurons with the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin. [PDF]

Neurotox Res
Casby J, Allen RK, Marron Fernandez de Velasco E, Thayer SA.   +3 more
europepmc   +1 more source