Results 231 to 240 of about 2,023,961 (292)

AI-Driven Design of High Affinity Biomolecule-Drug Conjugates for Gynecological Cancer Therapy: An Up-to-Date Narrative Review. [PDF]

Cancers (Basel)
Garg P, Horne D, Salgia R, Singhal SS.
europepmc   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

A budding science of illegal markets. [PDF]

Proc Natl Acad Sci U S A
Caulkins JP.
europepmc   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Antibody-Drug Conjugates in Contemporary Oncology: A Clinical Perspective on Dose Optimization, Sequencing, and Combination Strategies. [PDF]

Cancers (Basel)
Philipovskiy A, Shurmur S, Abid MB.
europepmc   +1 more source

Lipid-gated vesicular trafficking directs HSPA1A to the plasma membrane through the endo-lysosomal network. [PDF]

Cell Stress Chaperones
Low J, Cuaresma AB, Martin CK, Badolian A, AlSebaye M, Stahelin RV, Nikolaidis N.   +6 more
europepmc   +1 more source

Illegal Wildlife Trade in Kathmandu Valley: A Hub of Biodiversity Crime. [PDF]

Ecol Evol
Koju NP, Tamang BM.
europepmc   +1 more source

The Portuguese police experience with drug decriminalisation. [PDF]

Policing Soc
Moniz M, Ribeiro B, Thompson E, Del Pozo B.   +3 more
europepmc   +1 more source

Integrating family-based interventions into specialty court programs: qualitative guidance from sex trafficking specialty court participants and their supportive family members. [PDF]

Health Justice
Murnan A, Mahon J, Jackson G, Pate S, Thompson S, Stewart C, Brown J, Manchak S, Butsch Kovacic M.   +8 more
europepmc   +1 more source

The threat from Transnational Crime in Southeast Asia: Drug Trafficking, Human Smuggling and Trafficking and sea piracy.

Revista UNISCI, 2003
Ralf Emmers
doaj