Results 281 to 290 of about 4,204,718 (353)

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Na_v1.5 channels. [PDF]

Am J Physiol Heart Circ Physiol
Sauer J, Marksteiner J, Hohenegger M, Todt H, Kubista H, Dostal C, Kiss A, Podesser BK, Salzer I, Koenig X, Stary-Weinzinger A, Hilber K, Kudlacek O.   +12 more
europepmc   +1 more source

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

Advanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee, Eun Kyoung Kim, Hee Young Ju, Chae Rin Lee, Soyul Ahn, Eun‐Sun Kim, Kyungjae Myung, Won Kyu Kim, Su‐Yeon Cho, Yujin Kwon, Dokyoung Kim, Yeuni Yu, Eun Jung Kwon, Hyomin Kim, Seong Ik Mun, Dong Min Lim, Kihun Kim, Hye Jin Heo, Seung Eun Baek, Sun Young Lee, Hyunsoo Cho, Eun Young Choi, Tae Sik Goh, Ninib Baryawno, Dongjun Lee, Ki Sun Jung, Keon Hee Yoo, Chang‐Kyu Oh, Yun Hak Kim   +28 more
wiley   +1 more source

The threat from Transnational Crime in Southeast Asia: Drug Trafficking, Human Smuggling and Trafficking and sea piracy.

Revista UNISCI, 2003
Ralf Emmers
doaj  

Firearm-related violence in the Caribbean is a complex systemic issue: how do we move towards a solution? [PDF]

Lancet Reg Health Am
Sobers NP, Agard J, Norville K, Fabre AS, Florquin N, Joseph C, Joseph M, Garcia-Joseph M, King R, Toppin PJ, Wong H, Anderson SG.   +11 more
europepmc   +1 more source

On the issue of establishing extraterritorial jurisdiction over transnational crimes in the sphere of illegal trafficking in narcotic drugs and similar substances: international and legal analysis

I. Yu. Belyaev
openalex   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

Advanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li, Weijia Chen, Mengxue Sun, Xinbo Ni, Qishan Ran, Xiaoyu Hu, Fang Cao, Wenwen Zeng   +7 more
wiley   +1 more source

Decoding the structural and functional diversity of GABA_A receptors: from ensemble logic to therapeutic opportunities. [PDF]

Front Pharmacol
Treviño M, Guerra-Crespo M, Padilla-Godínez FJ, Soto-Rojas LO, Manjarrez E, Ortega-Robles E, Rodríguez-de Ita J, Arias-Carrión O.   +7 more
europepmc   +1 more source

Contrabando Y Corrupcion: The Rise in Popularity of Narcocorridos [PDF]

, 2001
Fernández, Celestino, Holscher, Louis M.   +1 more
core   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source