Results 261 to 270 of about 579,008 (311)
Caco-2 monolayers in experimental and theoretical predictions of drug transport
Advanced Drug Delivery Reviews, 2012 This review examines the use of Caco-2 monolayers in the prediction of intestinal drug absorption. First, the different routes of drug transport in Caco-2 monolayers are compared with those seen in vivo.
Per Artursson, Kristina Luthman
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Transporter-Mediated Drug–Drug Interactions
Pharmacogenomics, 2011Drug-drug interactions are a serious clinical issue. An important mechanism underlying drug-drug interactions is induction or inhibition of drug transporters that mediate the cellular uptake and efflux of xenobiotics. Especially drug transporters of the small intestine, liver and kidney are major determinants of the pharmacokinetic profile of drugs ...
Fabian, Müller, Martin F, Fromm
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Drug metabolism and drug transport of the 100 most prescribed oral drugs [PDF]
Basic and Clinical Pharmacology and Toxicology, 2022 Ditte B Iversen +2 more
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Pharmacogenetics of Drug Transporters
Current Pharmaceutical Design, 2010During the last decade, a greater focus has been given to impact of genetic variation in membrane transporters on the pharmacokinetics and toxicity of numerous therapeutic drugs. While the majority of transporter-related pharmacogenetic research has been in regards to classic genes encoding the outward-directed ATP-binding cassette (ABC) transporters ...
R M, Franke, E R, Gardner, A, Sparreboom
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Current Drug Metabolism, 2004
Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
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Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
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Renal Drug Transporters and Drug Interactions
Clinical Pharmacokinetics, 2017Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug ...
Ivanyuk A, Livio F, Biollaz J, Buclin T
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Drug Transporters in Drug Efficacy and Toxicity
Annual Review of Pharmacology and Toxicology, 2012Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary ...
M K, DeGorter +3 more
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Clinical Infectious Diseases, 1994
The ability of drugs to enter cells and to reach an adequate concentration within the appropriate intracellular compartment may be an important determinant of the efficacy of therapy for infections due to intracellular pathogens. Antibiotics vary considerably in their ability to accumulate within cells.
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The ability of drugs to enter cells and to reach an adequate concentration within the appropriate intracellular compartment may be an important determinant of the efficacy of therapy for infections due to intracellular pathogens. Antibiotics vary considerably in their ability to accumulate within cells.
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2002
A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
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A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
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Enzymes, Drugs and Transport Phenomena
Protoplasma, 1967Other contributors to this Symposium on Biophysics and Physiology of Biological Transport have dealt with the physicochemical aspects of membrane transport, what the membranes of cells and their organelles look like, how they behave physiologically, and the biochemical interpretation of the transport of isodium and potassium across such structures ...
K H, Beyer, J E, Baer
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