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Membrane transporters play a central role in protecting the body from xenobiotics (either by preventing their absorption, limiting their distribution, or promoting their elimination). Transporters can also participate in trafficking and compartmentalization of physiological compounds.
Talevi, Alan, Bellera, Carolina Leticia
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Talevi, Alan, Bellera, Carolina Leticia
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2001
The advantages of breast-feeding for both mother (maternal-infant bonding, cost savings, reduced risk of premenopausal breast cancer, etc.) and for the infant (bactericidal effects of lysozyme, presence of immunoglobulins, more readily digested, decrease in food allergy, lower incidence of obesity and morbidity, etc.) are compelling and ensure the ...
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The advantages of breast-feeding for both mother (maternal-infant bonding, cost savings, reduced risk of premenopausal breast cancer, etc.) and for the infant (bactericidal effects of lysozyme, presence of immunoglobulins, more readily digested, decrease in food allergy, lower incidence of obesity and morbidity, etc.) are compelling and ensure the ...
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Transport of Drugs across Membranes
Protoplasma, 1967In contrast to many compounds of physiological significance the penetration of drugs through membranes is, in general, passive, by diffusion or filtration. Most drugs are weak organic acids or bases, which in the unionized state are lipid soluble, but are hydrophilic when dissociated.
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1992
The blood-brain barrier (BBB) at cerebral capillaries consists of a continuous layer of endothelial cells connected by tight junctions (zonulae occludens). The capillary wall lacks water-filled channels of suitable size for aqueous diffusion (except for water itself), and the endothelial cell membranes lack carrier systems of suitable affinity for ...
P. J. Robinson, S. I. Rapoport
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The blood-brain barrier (BBB) at cerebral capillaries consists of a continuous layer of endothelial cells connected by tight junctions (zonulae occludens). The capillary wall lacks water-filled channels of suitable size for aqueous diffusion (except for water itself), and the endothelial cell membranes lack carrier systems of suitable affinity for ...
P. J. Robinson, S. I. Rapoport
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Drug transport across the placenta, role of the ABC drug efflux transporters
Expert Opinion on Drug Metabolism & Toxicology, 2007The placenta serves an important role both as a protective barrier as well as in normal fetal development. The ATP-binding cassette (ABC) proteins perform crucial functions in the distribution of nutrients and exchange of waste metabolites across the placenta.
Javad, Behravan +1 more
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Renal Drug Transport and Drug-Drug Interactions
Journal of Pharmacy Practice, 2002The kidney plays a vital role in the elimination of xenobiotics including drugs, toxins, and endogenous metabolites. Renal drug elimination involves 3 major processes: glomerular filtration, tubular secretion, and tubular reabsorption. Although glomerular filtration is a simple unidirectional diffusion process, renal tubular secretion and/or ...
Patrick T. Ronaldson, Reina Bendayan
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The impact of drug transporters on adverse drug reaction
European Journal of Drug Metabolism and Pharmacokinetics, 2013In this review, we have highlighted the adverse drug reaction mediated by transporters from two aspects: (1) competitive interactions between drug and drug/metabolite/endogenous substance mediated by transporters; (2) the expression/function change of transporter due to physiologic factors, disease, and drugs induction.
Yan, Zhou +8 more
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Drug Delivery and Drug Transport
2015Drug delivery is a key problem in the treatment of cancer. Most of the differences between tumor and host are quantitative, not qualitative. Therefore, untransformed cells have some sensitivity to many anti-cancer drugs. In particular, the conventional chemotherapy agents have high toxicity toward all proliferating cells, so it is essential that drug ...
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Drug transporters and renal drug disposition in the newborn
The Journal of Maternal-Fetal & Neonatal Medicine, 2009The individual response to a drug in terms of drug efficacy and toxicity is highly variable; this represents a major problem in clinical practice. Potential causes for such variability include pathogenesis and severity of the disease being treated, drug interactions, patient age, nutritional status, renal and liver function and concomitant illness ...
De Gregori S +5 more
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Drug transport and drug resistance in African trypanosomes
Drug Resistance Updates, 2003Drug resistance in African trypanosomes has been studied for almost a hundred years. Beginning with Paul Ehrlich's work that led to the chemoreceptor hypothesis, reduction of net drug uptake has emerged as the most frequent cause of resistance. This review, therefore, focuses on trypanosomal drug transporter genes.
Mäser P, Lüscher A, Kaminsky R
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