Results 111 to 120 of about 5,252,361 (312)
Factors associated with relapse among clients in Australian substance disorder treatment facilities [PDF]
, 2006 Factors associated with relapse to problematic alcohol or illicit drug use were examined in 104 clients enrolled in treatment programmes for substance disorders.
Hammerbacher, Melissa, Lyvers, Michael
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Substance Abuse Treatment, Prevention, and Policy, 2019 Background The purpose of this study was to assess what is associated with health service satisfaction among adults with a substance use disorder receiving services provided within different municipalities in Norway.
Marianne Stallvik +3 more
doaj +1 more source
Family, Peers and School Programs and the Influence on Juvenile Marijuana Use [PDF]
, 2010 Drug use has is a common form of deviance among adolescents. This paper focuses on the different ways that social institutions try to positively or negatively influence juveniles from becoming involved in drug use.
Vinciguerra, Victoria
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
EClinicalMedicine, 2019 Background: Heroin is currently contributing to the worst drug addiction epidemic in United States history; recent rates of use, dependence and death have also increased dramatically in parts of Europe.
Christina Marel +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Perceived impacts of North Americas first de-medicalized safer supply program
Substance Abuse Treatment, Prevention, and PolicyBackground The Drug User Liberation Front led an evaluation of a non-medicalized model of safer supply known as a “Compassion Club.” This club sourced, rigorously tested, packaged, and accurately labeled certain illicit substances and then provided them ...
Jeremy Kalicum +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source