Results 271 to 280 of about 839,545 (360)

Emergence of HCV genotype 6 and its new variants among intravenous drug users in Manipur, a north-eastern state of India. [PDF]

Ther Adv Infect Dis
Das R, Dutta S, Bakshi S, Biswas A, Nath S, Majumdar M, Verma P, Baskey U, Dutta S, Sadhukhan PC.   +9 more
europepmc   +1 more source

Correction: Are Current Drug Driving Enforcement Strategies Achieving the Desired Effect? Drug Users’ Perceptions of Drug Driving Legislation and Enforcement in Queensland [PDF]

Steven Love, Bevan Rowland, Kayla B. Stefanidis, Jeremy D. Davey   +3 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Risk Factors Associated with Pyogenic Spinal Infections among Intravenous Drug Users and Nonusers. [PDF]

Adv Orthop
Bilolikar VK, Gleason B, Kripke L, Merrill R, Whitaker C, Handal J.   +5 more
europepmc   +1 more source

Depressive Symptoms, Drug Network, and Their Synergistic Effect on Needle-Sharing Behavior Among Street Injection Drug Users

, 1999
Wallace Mandell, Joohyung Kim, Carl A. Latkin, Tongwoo Suh   +3 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Changing the High-Risk Behaviors of Injecting Drug Users in Iran: Application Theory of Planned Behavior. [PDF]

ScientificWorldJournal
Khani Jeihooni A, Mohammadkhah F, Bijani M, Harsini PA.   +3 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Ending the overdose epidemic by ending the war on drug users: Can this work? [PDF]

J Psychiatry Neurosci
Leyton M, Krausz RM.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source