Results 241 to 250 of about 412,569 (303)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Biomarker Utilization for Regulatory Decision Making: A Landscape Analysis of Neurological Drug Products Approved by FDA (2008-2024). [PDF]

Clin Pharmacol Ther
Jung D, Sabarinath S, Uppoor R, Mehta M, Zhang Y.   +4 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Health Technology Assessment of Oxazolidinones for MRSA-Associated Complicated Skin and Soft Tissue Infections. [PDF]

Drug Des Devel Ther
Zhao Y, Huang B, Yang Z, Kuang H, Chen J.   +4 more
europepmc   +1 more source

Modeling In-Hospital Mortality Among Patients Undergoing Percutaneous Coronary Intervention with Acute Myocardial Infarction Complicated by Cardiogenic Shock Receiving Mechanical Circulatory Support. [PDF]

Med Devices (Auckl)
Hurley NC, Mortazavi BJ, Dhruva SS, Ross JS, Ngufor CG, Curtis JP, Krumholz HM, Desai NR.   +7 more
europepmc   +1 more source

Evaluation of standard use of intravenous infusion in 25 general hospitals in Shanxi province based on factor analysis and cluster analysis. [PDF]

Front Pharmacol
Chen L, Wang S, Duan J, Yu R, Hou R, Yin D.   +5 more
europepmc   +1 more source

Beyond Missingness: Systematizing Methods for Comprehensive Data Fitness Assessment in Clinical Research.

J Med Internet Res
Razzaghi H, Wieand K, Dickinson KL, Kahn MG, Roy J, Blacketer C, Christakis DA, Forrest CB, Greenberg J, Lehmann HP, Marsolo KA, Sciolla J, Weiner MG, Weiskopf NG, Bailey LC.   +14 more
europepmc   +1 more source

Economic Evaluation of Ready-to-Dilute Thiotepa (Tepylute^®): Institutional Cost Offsets and Time Savings Compared to Lyophilized Thiotepa in a United States Hospital Pharmacy. [PDF]

Clinicoecon Outcomes Res
Ryan O, Clancy M, MacDonald A, Pastor L, Bourque M.   +4 more
europepmc   +1 more source

The equity gap in precision dosing: a cross-sectional analysis of hospital-wide antimicrobial therapeutic drug monitoring implementation. [PDF]

Front Public Health
Yang B, Zheng B, Wang J, Jiang H, Yang W, Xu H, Han B, Xin C, Zhang M, Tu Y.   +9 more
europepmc   +1 more source