Results 41 to 50 of about 49,873 (269)

Effects of Chinese Herbal Medicines on Intestinal Drug Absorption

YAKUGAKU ZASSHI, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +3 more sources

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Exploration of medication patterns and new formulas for patented Chinese herbal medicine compound therapy for colorectal cancer in the past 20 years

Zhongguo linchuang yanjiu
Objective To analyze the medication usage and compatibility patterns of Chinese herbal medicine compound formulas in patents for intervening in colorectal cancer (CRC) over the past 20 years based on data mining, in order to provide a foundation for the ...
ZHANG Zhaoyang , YANG Hao, WU Tengfei, ZHU Chongwei, TIAN Yun   +4 more
doaj   +1 more source

Efficacy and potential mechanisms of Chinese herbal compounds in coronavirus disease 2019: advances of laboratory and clinical studies

Chinese Medicine, 2021
The Coronavirus disease 2019 (COVID-19) pandemic is still spread and has made a severe public health threat around the world. To improve disease progression, emerging Chinese herbal compounds were used in clinical practice and some agents have proven ...
Mu-Feng Xiang, Cheng-Tao Jin, Li-Hua Sun, Zhi-Hui Zhang, Jing-Jing Yao, Liu-Cheng Li   +5 more
doaj   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Polygonatum cyrtonema Hua fructan ameliorates ulcerative colitis via gut microbiota modulation and follistatin targeting

npj Science of Food
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with persistent colonic inflammation and inadequate therapeutic options. The medicinal and edible plant Polygonatum cyrtonema Hua from Jiuhua Mountain contains polysaccharides with potent ...
Qiangbao Xu, Qiuyue Lv, Zhu Yang, Yiping Yang, Zihan Li, Yingying Zhang, Lingzhi Chen, Sumiao Zhan, Hui Che, Guodong Wang, Jiangping Wu, Jun Han   +11 more
doaj   +1 more source

Drug innovation via integration of traditional Chinese and Western medicine

Science of Traditional Chinese Medicine
. Innovative drugs are defined as new chemical entities that play a vital role in the treatment and maintenance of human health. While single-target innovative drugs have achieved notable success, they face limitations in addressing the increasingly ...
Zhineng Li, Le Yang, Ling Kong, Hui Sun, Ye Sun, Xiangmei Chen, Fengting Yin, Guangli Yan, Xijun Wang   +8 more
doaj   +1 more source

Effects of alkaloids on peripheral neuropathic pain: a review

Chinese Medicine, 2020
Neuropathic pain is a debilitating pathological pain condition with a great therapeutic challenge in clinical practice. Currently used analgesics produce deleterious side effects.
Chunhao Zhu, Ning Liu, Miaomiao Tian, Lin Ma, Jiamei Yang, Xiaobing Lan, Hanxiang Ma, Jianguo Niu, Jianqiang Yu   +8 more
doaj   +1 more source

Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines

Acta Pharmacologica Sinica, 2022
Traditional medicine has provided a basis for health care and disease treatment to Chinese people for millennia, and herbal medicines are regulated as drug products in China. Chinese herbal medicines have two features. They normally possess very complex chemical composition.
Li, Chuan, Jia, Wei-wei, Yang, Jun-ling, Cheng, Chen, Olaleye, Olajide E.   +4 more
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