Results 41 to 50 of about 49,463 (306)

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Exploration of medication patterns and new formulas for patented Chinese herbal medicine compound therapy for colorectal cancer in the past 20 years

Zhongguo linchuang yanjiu
Objective To analyze the medication usage and compatibility patterns of Chinese herbal medicine compound formulas in patents for intervening in colorectal cancer (CRC) over the past 20 years based on data mining, in order to provide a foundation for the ...
ZHANG Zhaoyang , YANG Hao, WU Tengfei, ZHU Chongwei, TIAN Yun   +4 more
doaj   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Polygonatum cyrtonema Hua fructan ameliorates ulcerative colitis via gut microbiota modulation and follistatin targeting

npj Science of Food
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with persistent colonic inflammation and inadequate therapeutic options. The medicinal and edible plant Polygonatum cyrtonema Hua from Jiuhua Mountain contains polysaccharides with potent ...
Qiangbao Xu, Qiuyue Lv, Zhu Yang, Yiping Yang, Zihan Li, Yingying Zhang, Lingzhi Chen, Sumiao Zhan, Hui Che, Guodong Wang, Jiangping Wu, Jun Han   +11 more
doaj   +1 more source

Drug innovation via integration of traditional Chinese and Western medicine

Science of Traditional Chinese Medicine
. Innovative drugs are defined as new chemical entities that play a vital role in the treatment and maintenance of human health. While single-target innovative drugs have achieved notable success, they face limitations in addressing the increasingly ...
Zhineng Li, Le Yang, Ling Kong, Hui Sun, Ye Sun, Xiangmei Chen, Fengting Yin, Guangli Yan, Xijun Wang   +8 more
doaj   +1 more source

Effects of alkaloids on peripheral neuropathic pain: a review

Chinese Medicine, 2020
Neuropathic pain is a debilitating pathological pain condition with a great therapeutic challenge in clinical practice. Currently used analgesics produce deleterious side effects.
Chunhao Zhu, Ning Liu, Miaomiao Tian, Lin Ma, Jiamei Yang, Xiaobing Lan, Hanxiang Ma, Jianguo Niu, Jianqiang Yu   +8 more
doaj   +1 more source

Efficacy and potential mechanisms of Chinese herbal compounds in coronavirus disease 2019: advances of laboratory and clinical studies

Chinese Medicine, 2021
The Coronavirus disease 2019 (COVID-19) pandemic is still spread and has made a severe public health threat around the world. To improve disease progression, emerging Chinese herbal compounds were used in clinical practice and some agents have proven ...
Mu-Feng Xiang, Cheng-Tao Jin, Li-Hua Sun, Zhi-Hui Zhang, Jing-Jing Yao, Liu-Cheng Li   +5 more
doaj   +1 more source

Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines [PDF]

Chinese Medicine, 2010
Abstract Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein.
Lin Ge, To Kenneth KW, Chai Stella
openaire   +3 more sources

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source