Results 51 to 60 of about 84,078 (314)

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Exploration of medication patterns and new formulas for patented Chinese herbal medicine compound therapy for colorectal cancer in the past 20 years

Zhongguo linchuang yanjiu
Objective To analyze the medication usage and compatibility patterns of Chinese herbal medicine compound formulas in patents for intervening in colorectal cancer (CRC) over the past 20 years based on data mining, in order to provide a foundation for the ...
ZHANG Zhaoyang , YANG Hao, WU Tengfei, ZHU Chongwei, TIAN Yun   +4 more
doaj   +1 more source

Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid. [PDF]

PLoS ONE, 2014
Both end-stage renal disease (ESRD) and urothelial cancer (UC) are associated with the consumption of Chinese herbal products containing aristolochic acid (AA) by the general population.
Shuo-Meng Wang, Ming-Nan Lai, Alan Wei, Ya-Yin Chen, Yeong-Shiau Pu, Pau-Chung Chen, Jung-Der Wang   +6 more
doaj   +1 more source

Oxidation and Reduction Dual-Responsive Polymeric Prodrug Micelles Co-delivery Precisely Prescribed Paclitaxel and Honokiol for Laryngeal Carcinoma Combination Therapy

Frontiers in Pharmacology, 2022
Laryngeal carcinoma is the most common head and neck malignancy globally, and chemotherapy is still the most common treatment for this type of carcinoma.
Lanzhu Zhou, Jun Wu, Zhe Sun, Wenzhong Wang   +3 more
doaj   +1 more source

Concurrent use of prescription drugs and herbal medicinal products in older adults: A systematic review [PDF]

, 2017
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction ...
A Cherubini, A Djuv, A Fugh-Berman, A Gonzalez-Stuart, A Robinson, A Tsang, AA Izzo, AA Izzo, AA Mangoni, AM Loya, Barbara Wider, C Batanero-Hernán, CA Parkman, CC Peng, Claire Goodman, Commission of the European Communities, DH Mehta, DM Qato, DM Qato, DW Kaufman, E Vacas Rodilla, EC Davies, EM Williamson, FP Turkmenoglu, G Nyborg, GW Elmer, J Jerez-Roig, J Kavanagh, J Kennedy, J Ly, J Peklar, J Sultana, JE Souza Silva de, JJ Bruno, JM Dergal, JS Marinac, K Radimer, KA Vickers, L Howell, L Shamseer, L Shane-McWhorter, Leala K. Watson, MA Raji, ME Levine, MHRA, Ipsos MORI, MS Lantz, N Lynch, N Samuels, P Gardiner, P Posadzki, PH Canter, R Delgoda, RL Nahin, S Hilmer, S Singh, S Yoon, SJ Blalock, SJ Yoon, SL Yoon, SR Singh, T Agbabiaka, Taofikat B. Agbabiaka, The Joanna Briggs Institute, W Leiss, X-L Zhang, Z Munn   +65 more
core   +2 more sources

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Drug innovation via integration of traditional Chinese and Western medicine

Science of Traditional Chinese Medicine
. Innovative drugs are defined as new chemical entities that play a vital role in the treatment and maintenance of human health. While single-target innovative drugs have achieved notable success, they face limitations in addressing the increasingly ...
Zhineng Li, Le Yang, Ling Kong, Hui Sun, Ye Sun, Xiangmei Chen, Fengting Yin, Guangli Yan, Xijun Wang   +8 more
doaj   +1 more source

Evaluation of efficacy and safety of Qiangzhu-qinggan formula as an adjunctive therapy in adult patients with severe influenza: study protocol for a randomized parallel placebo-controlled double-blind multicenter trial

Trials, 2021
s Background Influenza can fall into three categories according to severity: mild influenza, severe influenza, and critical influenza. Severe influenza can result in critical illness and sometimes death particularly in patients with comorbidities ...
Lei Qiu, Xian-wei Wu, Shao-yan Zhang, Ming Yang, Shun-xian Zhang, Ji-you Fu, Cui Li, Zhi-jie Zhang, Pei-yong Zheng, Zhen-hui Lu   +9 more
doaj   +1 more source

Review of the Efficacy and Mechanisms of Traditional Chinese Medicines as a Therapeutic Option for Ionizing Radiation Induced Damage

Frontiers in Pharmacology, 2021
Ionizing radiation damage refers to acute, delayed, or chronic tissue damage associated with ionizing radiation. Specific or effective therapeutic options for systemic injuries induced by ionizing radiation have not been developed.
Xiaomeng Zhang, Xiaoying Chen, Lei Wang, Changhao He, Zhongyu Shi, Qian Fu, Wenhui Xu, Shujing Zhang, Sumin Hu   +8 more
doaj   +1 more source

Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network. [PDF]

, 2019
Traditional Chinese Medicine (TCM) has received increasing attention as a complementary approach or alternative to modern medicine. However, experimental methods for identifying novel targets of TCM herbs heavily relied on the current available herb ...
Chen, Jianxin, Gao, Zhuye, Hu, Xiaochen, Li, Peng, Liu, Baoyan, Peng, Yonghong, Wang, Ning, Xu, Hao, Yang, Kuo, Zhang, Runshun, Zhou, Xuezhong, Zhu, Qiang   +11 more
core   +1 more source