Results 51 to 60 of about 82,737 (314)

Oxidation and Reduction Dual-Responsive Polymeric Prodrug Micelles Co-delivery Precisely Prescribed Paclitaxel and Honokiol for Laryngeal Carcinoma Combination Therapy

Frontiers in Pharmacology, 2022
Laryngeal carcinoma is the most common head and neck malignancy globally, and chemotherapy is still the most common treatment for this type of carcinoma.
Lanzhu Zhou, Jun Wu, Zhe Sun, Wenzhong Wang   +3 more
doaj   +1 more source

Artemisinin: From Chinese Herbal Medicine to Modern Chemotherapy [PDF]

, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material.
Butler, Anthony
core   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Drug innovation via integration of traditional Chinese and Western medicine

Science of Traditional Chinese Medicine
. Innovative drugs are defined as new chemical entities that play a vital role in the treatment and maintenance of human health. While single-target innovative drugs have achieved notable success, they face limitations in addressing the increasingly ...
Zhineng Li, Le Yang, Ling Kong, Hui Sun, Ye Sun, Xiangmei Chen, Fengting Yin, Guangli Yan, Xijun Wang   +8 more
doaj   +1 more source

Evaluation of efficacy and safety of Qiangzhu-qinggan formula as an adjunctive therapy in adult patients with severe influenza: study protocol for a randomized parallel placebo-controlled double-blind multicenter trial

Trials, 2021
s Background Influenza can fall into three categories according to severity: mild influenza, severe influenza, and critical influenza. Severe influenza can result in critical illness and sometimes death particularly in patients with comorbidities ...
Lei Qiu, Xian-wei Wu, Shao-yan Zhang, Ming Yang, Shun-xian Zhang, Ji-you Fu, Cui Li, Zhi-jie Zhang, Pei-yong Zheng, Zhen-hui Lu   +9 more
doaj   +1 more source

Review of the Efficacy and Mechanisms of Traditional Chinese Medicines as a Therapeutic Option for Ionizing Radiation Induced Damage

Frontiers in Pharmacology, 2021
Ionizing radiation damage refers to acute, delayed, or chronic tissue damage associated with ionizing radiation. Specific or effective therapeutic options for systemic injuries induced by ionizing radiation have not been developed.
Xiaomeng Zhang, Xiaoying Chen, Lei Wang, Changhao He, Zhongyu Shi, Qian Fu, Wenhui Xu, Shujing Zhang, Sumin Hu   +8 more
doaj   +1 more source

Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines [PDF]

Chinese Medicine, 2010
Abstract Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein.
Lin Ge, To Kenneth KW, Chai Stella
openaire   +3 more sources

Is there a potential of misuse for Magnolia officinalis compounds/metabolites? [PDF]

, 2017
© 2017 John Wiley & Sons, Ltd.Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers ...
Alexeev, Böhmdorfer, Chiou, Coppola, Fattore, Fuchs, Fuchs, Garrison, Hattori, Kalman, Kao, Kotani, Kuribara, Lee, Lee, Lin, Liu, Mantani, Nakazawa, Oikawa, Papanti, Rempel, Schifano, Schifano, Schifano, Siemann, Sohn, Squires, Tsai, Tsai, Wang, Watanabe, Xu   +32 more
core   +3 more sources

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Exploring the evidence base for acupuncture in the treatment of Meniere’s Syndrome — A systematic review [PDF]

, 2011
Meniere’s syndrome is a long-term, progressive disease that damages the balance and hearing parts of the inner ear. To address the paucity of information on which evidence-based treatment decisions should be made, a systematic review of acupuncture for
Brettle, A, Long, AF, Morgan, K, Xing, M
core   +4 more sources