Results 171 to 180 of about 4,947,726 (309)
ADMET Profiling of the Metallodrugs: A Comparative Review of Platinum, Palladium, Gold, Ruthenium, Copper, and Zinc Anticancer Complexes. [PDF]
Bioinorg Chem ApplTini MK +5 more
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Optimizing Drug Procurement Using ABC-VEN: A Narrative Review and Conceptual Framework. [PDF]
J Multidiscip HealthcHeryanto D, Amalia E, Kautsar AP.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Are drugs for rare diseases "essential"?
Bulletin of the World Health OrganizationMarcus M Reidenberg
doaj +1 more source
Reforma del sector salud y la política farmacéutica en Perú
Cadernos de Saúde PúblicaEste artículo analiza el Programa de Administración Compartida de Farmacias (PACFARM) y su articulación con la Política Farmacéutica en Perú, en el contexto de la reforma del sector salud. La ejecución de los diversos Programas de Medicamentos Esenciales
Carmen Phang Romero
doaj
Special Issue: Toxicity of Metals, Metal-Based Drugs, and Microplastics. [PDF]
Int J Mol SciŚcibior A, Aureliano M, Llopis J.
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular mechanisms underlying drug resistance in protozoan parasites: emerging mechanisms and therapeutic perspectives. [PDF]
Front ParasitolUduwela K, Ranasinghe K.
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source