Results 151 to 160 of about 4,947,726 (309)

Drug use patterns at a Kenyan referral hospital: A cross-sectional study using WHO core indicators. [PDF]

PLoS One
Chacha RC, Terefe EM.
europepmc   +1 more source

Report of side effects associated with the use of drugs 1981

, 1981
The National Drugs Advisory Board received 662 reports during 1981 from which 1264 side-effects were recorded. Of these 33.3% concerned drugs affecting the central nervous system and 27% involved anti-infective drugs. Of the drugs affecting the central
National Drugs Advisory Board (NDAB)
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Essential antiarrhythmic drug accessibility worldwide: a multi-survey study and comprehensive evaluation of access and supply challenges. [PDF]

Europace
Postema PG, Reijnhout ND, Ballacci F, Manders EA, Hoeksema WF, Toniolo M, Tfelt-Hansen J, Penela D, Futyma P, Lane DA, Casado-Arroyo R, Sarquella-Brugada G, Blom NA, Wilde AAM, Hollak CEM, Arbelo E.   +15 more
europepmc   +1 more source

The essential drugs concept and its implementation / M. Helling-Borda

, 1985
ONLINEDAP/85.1.
Helling-Borda, M, WHO Action Programme on Essential Drugs   +1 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fortifying essential medicines supply chains in Sub-Saharan Africa - the curious cases of Kenya and Uganda. [PDF]

Glob Health Action
Kludze M, Hussein M.
europepmc   +1 more source

Reports of side effects associated with the use of drugs 1968-1975

, 1976
The National Drugs Advisory Board received 716 reports from medical and dental practitioners during 1975. From these 1180 side-effects were recorded associated with the use of drugs during the year.
National Drugs Advisory Board (NDAB)
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Target-biology and interactome-derived signatures predict target-level associations with safety-related drug attrition. [PDF]

Sci Rep
Breffle J, Jones A, Ghiassian SD.
europepmc   +1 more source