Results 131 to 140 of about 9,616,743 (356)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Indian Essential Medicine List for mental disorders: Time to revisit

Annals of Medical Science and Research
Background: Management of mental health issues remains far from satisfactory. The majority of these mental health disorders can be effectively managed by ensuring the availability of quality drugs in appropriate dosage forms.
Divya Goel, Arnav Gupta
doaj   +1 more source

Developing and Distributing Essential Medicines to Poor Countries: The DEFEND Proposal [PDF]

The poorest nations of the world suffer from extreme disease burdens, which go largely untreated because weak incomes and the prevailing system of intellectual property rights fail to provide sufficient incentives to develop new treatments and distribute
Ganslandt, Mattias, Maskus, Keith E., Wong, Eina V.   +2 more
core  

Ketersediaan dan Peresepan Obat Generik dan Obat Esensial di Fasilitas Pelayanan Kefarmasian di 10 Kabupaten/kota di Indonesia [PDF]

, 2010
Background: The Ministry of Health has a special guidance for increasing the utilization of generic drugs in governmental health facilities. Beside, The Ministry of Health also has regulation for writing a generic drugs prescription at governmental ...
Handayani, R. S. (Rini), Raharni, R. (Raharni), Supardi, S. (Sudibyo), Susyanty, A. L. (Andi)   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Impact of COVID-19 on Pharmaceutical Shortages and Supply Disruptions for Non-Communicable Diseases Among Public Hospitals of South West, Oromia, Ethiopia

Journal of Multidisciplinary Healthcare, 2022
Wakuma Wakene Jifar, Getachew Befekadu Geneti, Sileshi Dubale Dinssa Department of Pharmacy, College of Health Sciences, Mattu University, Mettu, EthiopiaCorrespondence: Wakuma Wakene Jifar, Department of Pharmacy, College of Health Sciences, Mattu ...
Jifar WW, Geneti GB, Dinssa SD
doaj  

Towards universal health coverage: lessons from 10 years of healthcare reform in China. [PDF]

, 2020
Universal health coverage (UHC) is driving the global health agenda. Many countries have embarked on national policy reforms towards this goal, including China. In 2009, the Chinese government launched a new round of healthcare reform towards UHC, aiming
Chuong, Linh, Dang, Haixia, Kominski, Gerald F, Li, Weimin, Lu, Bingqing, Tao, Wenjuan, Wen, Jin, Yue, Dahai, Zeng, Zhi, Zhao, Rui   +9 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source