Results 41 to 50 of about 9,616,743 (356)
Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes
Cell, 2017 Summary The genomes of malaria parasites contain many genes of unknown function. To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei
Ellen S C Bushell +17 more
semanticscholar +1 more source
Journal of Molecular Structure, 2020 COVID-19, caused by SARS-CoV-2 has recently emerged as a global pandemic. Intense efforts are ongoing to find a vaccine or a drug to control the disease across the globe.
S. Kulkarni +5 more
semanticscholar +1 more source
Revista Panamericana de Salud PúblicaObjective. The rational use of medicines offers a cost-saving strategy to maximize therapeutic outcomes for developing and developed countries. The aim of this study was to evaluate the rational use of medicines for selected noncommunicable diseases ...
Donna-Marie Wynter-Adams +4 more
doaj +1 more source
, 2008 OBJECTIVES: To examine the extent to which costs of subsidized antiretrovirals treatment (ART) programmes are catastrophic and the benefit incidence that accrues to different population groups.
Chukwuka, Chinwe +6 more
core +1 more source
Epigenetics-targeted drugs: current paradigms and future challenges
Signal Transduction and Targeted TherapyEpigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation.
Wanlin Dai +11 more
semanticscholar +1 more source
Abolishing user fees for children and pregnant women trebled uptake of malaria-related interventions in Kangaba, Mali. [PDF]
, 2011 Malaria is the most common cause of morbidity and mortality in children under 5 in Mali. Health centres provide primary care, including malaria treatment, under a system of cost recovery.
Audibert +15 more
core +2 more sources
Evidence-Based Complementary and Alternative Medicine, 2014 Candidosis is the most important cause of fungal infections in humans. The yeast Candida albicans can form biofilms, and it is known that microbial biofilms play an important role in human diseases and are very difficult to treat. The prolonged treatment
A. Stringaro +8 more
semanticscholar +1 more source
Antiretroviral medications for pediatric use in the context of the Unified Health System: are there therapeutic gaps in Brazil? [PDF]
Revista Paulista de PediatriaObjective: To evaluate the incorporation and adequacy of antiretrovirals for the treatment of HIV in children within the context of the Unified Health System in Brazil.
Suelen Martins da Costa +1 more
doaj +1 more source
Improving antibiotic prescribing for children in the resource-poor setting. [PDF]
, 2015 Antibiotics are a critically important part of paediatric medical care in low- and middle-income countries (LMICs), where infectious diseases are the leading cause of child mortality. The World Health Organization estimates that >50% of all medicines are
Barker, CI +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source