Results 221 to 230 of about 104,914 (293)

A One‐Strength Dose Escalation Regimen for Birch Pollen SCIT Is Safe and Tolerable in Children, Adolescents, and Adults

open access: yesAllergy, EarlyView.
This study evaluated safety and tolerability of birch pollen SCIT during dose escalation with a new One‐Strength regimen (3 injections, Strength B) compared to the Standard regimen (7 injections, Strengths A and B) in patients aged 5–65 years. Safety and tolerability were comparable between the two regimens in adults, adolescents, and adolescents, as ...
Marek Jutel   +5 more
wiley   +1 more source

Effect of Intramuscular Adrenaline on Histamine‐Induced Hypotension: A Randomised Placebo‐Controlled Pilot Trial

open access: yesAllergy, EarlyView.
Histamine infusions induce reproducible severe hypotension. Intramuscular adrenaline showed ‘supposedly therapeutic’ plasma concentrations but did not produce a sustained clinically relevant improvement in shock in the majority of recipients. These findings question adrenaline pharmacokinetic surrogate thresholds and support the need for faster and ...
Matthias Weiss‐Tessbach   +12 more
wiley   +1 more source

Navigating Oral Food Challenges in Clinical Trials to Keep the Science Moving Forward

open access: yesAllergy, EarlyView.
ABSTRACT The oral food challenge (OFC) has long been the reference standard for food allergy diagnosis, as well as to confirm natural development of oral tolerance. The utilization of OFCs has significantly broadened from its role in defining disease to defining participant eligibility, individual allergen reactivity thresholds and treatment outcomes ...
Edwin H. Kim   +10 more
wiley   +1 more source

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

open access: yesAllergy, EarlyView.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki   +6 more
wiley   +1 more source

Direct pulmonary delivery route in lung cancer: a highway for siRNA therapeutics. [PDF]

open access: yesFront Oncol
Sharif MS   +4 more
europepmc   +1 more source

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