Results 131 to 140 of about 3,598,260 (304)

Stimuli-Responsive Cell-Mimetic Vesicles for Advanced Pharmaceutical Systems

International Journal of Nanomedicine
Hyewon Jeon,1 Jaehyun Cheong,1 Jain Koo,1 Chaehyeon Ha,1 Hyunjung Cho,1 Seunghee Cheon,1 Kyung Taek Oh1,21Department of Global Innovative Drugs, The Graduate School of Chung-Ang University, Seoul, Republic of Korea; 2College of Pharmacy, Chung-Ang ...
Jeon H, Cheong J, Koo J, Ha C, Cho H, Cheon S, Oh KT   +6 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Development and Study of Hydrophilic Ointment Compositions with a Dextrin/Polyvinyl Alcohol/Iodine Complex (D/PVA/I)

Pharmaceuticals
Background: Iodine-based antimicrobial systems remain highly attractive due to their broad-spectrum activity; however, the clinical application of free iodine is limited by its instability and cytotoxicity. This study aimed to develop polyethylene glycol
Zhassur Taganov, Anel Azamatova, Roza Karzhaubayeva, Gulshat Baigaipova, Zhanar Iskakbayeva, Saltanat Jumabayeva, Ardak Jumagaziyeva, Ilya Korotetskiy, Lyudmila Ivanova, Natalya Zubenko, Seitzhan Turganbay, Amir Azembayev   +11 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Challenges of sharing individual participant data for secondary research on neglected tropical diseases: the experience of Drugs for Neglected Diseases initiative and a call for action

BMJ Open
Introduction The Drugs for Neglected Diseases initiative (DNDi) is committed to maximising the scientific value of the individual participant data (IPD) it has collected during its 20 years of activity and the IPD it will collect in the future, while ...
Anastassia Negrouk, Thaddaeus Egondi, Craig Tipple, Justyna Tarwid, Michelle Childs, Dominique Junod-Moser   +5 more
doaj   +1 more source

New drugs, old drugs - dear drugs, cheap drugs

Swiss Medical Weekly, 2002
Hirschel, Bernard, Garbino, Jorge
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Taskforce on Illicit Drugs reports

, 2020
Report A: Letter from the Chairperson, Membership, Terms of Reference, Glossary and Acronyms Report B: Executive Summary and ecommendations: 1. Introduction 2. Trends in the Use of Illicit Drugs in the Northern Territory 3. Prevention 4.
Taskforce on Illicit Drugs
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source