Results 311 to 320 of about 9,783,797 (388)

DRUGS WHICH ANTAGONIZE 5‐HYDROXYTRYPTAMINE

, 1954
J. H. Gaddum, Khan A. Hameed
openalex   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Consideration on Food Effect Studies for Anticancer Drugs Approved in Japan Between 2001 and 2022. [PDF]

Clin Transl Sci
Shibuya M, Kubota H, Maeda H.
europepmc   +1 more source

Drugs education in schools : an update [PDF]

, 2002

core  

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Disproportionality analysis and risk factor assessment of drug-associated thyroid dysfunction adverse events: a study based on the FAERS database. [PDF]

Endocr Connect
Wang Z, Wang Y, Wu T, Zhu H, Zhang L, Liao X.   +5 more
europepmc   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

The family herbal, or, An account of all those English plants, which are remarkable for their virtues, and of the drugs which are produced by vegetables of other countries; with their descriptions and their uses, as proved by experience ...

John D. Hill
openalex   +2 more sources

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Utilisation of drugs with pharmacogenetic recommendations in children in Switzerland. [PDF]

Pharmacogenomics J
Wittwer NL, Meier CR, Huber CA, Tilen R, Yilmaz C, Meyer Zu Schwabedissen HE, Allemann S, Schneider C.   +7 more
europepmc   +1 more source