Results 31 to 40 of about 6,707,659 (315)
Senolytic drugs: from discovery to translation
Journal of Internal Medicine, 2020 Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven approach.
J. Kirkland, T. Tchkonia
semanticscholar +1 more source
Jornal Brasileiro de Nefrologia, 2014 A doenca renal cronica (DRC), considerada a grande epidemia deste milenio, tem prevalencia media de 11% nos paises desenvolvidos. Infelizmente, no Brasil ainda nao dispomos de dados definitivos sobre a prevalencia da DRC, contudo, estudo realizado em amostra de 24.248 individuos adultos, utilizando o criterio de DRC baseado em duas determinacoes da ...
openaire +2 more sources
DrugBank: a knowledgebase for drugs, drug actions and drug targets
Nucleic Acids Res., 2007 DrugBank is a richly annotated resource that combines detailed drug data with comprehensive drug target and drug action information. Since its first release in 2006, DrugBank has been widely used to facilitate in silico drug target discovery, drug design,
D. Wishart +7 more
semanticscholar +1 more source
An Update on Current Therapeutic Drugs Treating COVID-19
Current Pharmacology Reports, 2020 The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there
Renyi Wu +13 more
semanticscholar +1 more source
Interprofessional Approach to Increase Billable Care-Events in a Rural Community
INNOVATIONS in Pharmacy, 2017 Objectives: The study was designed to build a financially stable, replicable, and interprofessional program around a Center of Excellence (COE) model exclusively in a community pharmacy setting.
Geoffrey A Twigg +3 more
doaj +1 more source
Interaction between drugs and the gut microbiome
Gut, 2020 The human gut microbiome is a complex ecosystem that can mediate the interaction of the human host with their environment. The interaction between gut microbes and commonly used non-antibiotic drugs is complex and bidirectional: gut microbiome ...
R. Weersma, A. Zhernakova, Jingyuan Fu
semanticscholar +1 more source
A review: Mechanism of action of antiviral drugs
International Journal of Immunopathology and Pharmacology, 2021 Antiviral drugs are a class of medicines particularly used for the treatment of viral infections. Drugs that combat viral infections are called antiviral drugs. Viruses are among the major pathogenic agents that cause number of serious diseases in humans,
S. Kausar +9 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware +13 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij +11 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
wiley +1 more source