Results 31 to 40 of about 3,396,597 (298)

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Drug–Drug Noninteractions

open access: yesCardiovascular Therapeutics, 2009
Understanding and documentation of drug–drug interactions (DDIs) are an important component of drug development, and of clinical therapeutics. Because clinical DDI studies are costly, time‐consuming, and involve some risk, not all clinical DDI questions can be realistically addressed through human DDI trials.In vitromodels have been used to identify ...
openaire   +3 more sources

Evaluation of eight lateral flow tests for the detection of anti-SARS-CoV-2 antibodies in a vaccinated population

open access: yesBMC Infectious Diseases, 2023
Background Rapid determination of an individual’s antibody status can be beneficial in understanding an individual’s immune response to SARS-CoV-2 and for initiation of therapies that are only deemed effective in sero-negative individuals.
Caitlin Greenland-Bews   +21 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Drug-drug interaction

open access: yesJornal Brasileiro de Nefrologia, 2014
A doenca renal cronica (DRC), considerada a grande epidemia deste milenio, tem prevalencia media de 11% nos paises desenvolvidos. Infelizmente, no Brasil ainda nao dispomos de dados definitivos sobre a prevalencia da DRC, contudo, estudo realizado em amostra de 24.248 individuos adultos, utilizando o criterio de DRC baseado em duas determinacoes da ...
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Oxoammonium salts are catalysing efficient and selective halogenation of olefins, alkynes and aromatics

open access: yesNature Communications, 2021
Organohalides are widely used as synthetic precursors and target products, but for various halogenation reactions there is a need for effective catalysts to activate commercially available haleniums.
Weijin Wang   +6 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs

open access: yesCancer Cell International, 2018
Background Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of both to intrinsic resistance is ...
Bodo Haas   +12 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

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