Results 41 to 50 of about 11,599 (182)

Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou, Kalliopi Christopoulou, Amalia D. Kalampaliki, Aikaterini F. Giannopoulou, Eleftheria Chatziorfanou, Vivi Bafiti, Andreas Krämer, Athanasios Papakyriakou, Dimitrios J. Stravopodis, Stefan Knapp, Ioannis K. Kostakis   +10 more
wiley   +1 more source

High‐Performance Recycling Biobased Photopolymers for 3D Printing

Advanced Science, Volume 13, Issue 32, 9 June 2026.
By using biobased phenols like eugenol, novel biobased photopolymers containing dissociative phenol‐carbamate bonds are designed for 3D printing. Meanwhile, a “mixed‐monomer assisted recycling” strategy is proposed to recycle the materials. The resulting materials not only achieve high‐performance and excellent chemical recyclability simultaneously ...
Hang Zhou, Yi Tan, Chuanwei Lu, Yanlin Li, Tianyi Tang, Zheng Yang, Ying Li, Xuehan Chen, Jianfeng Yao, Zhengchun Cai, Yuanyuan Jiang, Ping Zhao, Chengguo Liu   +12 more
wiley   +1 more source

A comprehensive simulation analysis of LTE Discontinuous Reception (DRX)

Computer Networks, 2014
In an LTE cell, Discontinuous Reception (DRX) allows the central base station to configure User Equipments for periodic wake/sleep cycles, so as to save energy. DRX operations depend on several parameters, which can be tuned to achieve optimal performance with different traffic profiles (i.e., CBR vs. bursty, periodic vs. sporadic, etc.).
STEA, GIOVANNI, VIRDIS, ANTONIO
openaire   +2 more sources

Dissolution and reprecipitation of 14H-LPSO structure accompanied by dynamic recrystallization in hot-extruded Mg89Y4Zn2Li5 alloy

Journal of Magnesium and Alloys, 2023
We investigate the variation induced in long-period stacking ordered (LPSO) structures, dynamic recrystallization (DRX), and mechanical performance of hot-extruded Mg89Y4Zn2Li5 alloys fabricated at different extrusion speeds (Ve = 0.4, 0.8, 1.0, 1.2 mm/s)
Wei Liu, Yu Su, Yuntao Zhang, Liwen Chen, Hua Hou, Yuhong Zhao   +5 more
doaj   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1552-1566, June 2026.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Dynamic recrystallization behavior of as-cast AZ91 magnesium alloy during hot compressive

Journal of Materials Research and Technology, 2022
This work systematically studies the dynamic recrystallization (DRX) behavior of as-cast AZ91 magnesium alloy under hot compression deformation at 350 °C.
Shiwei Xu, Congcong Zhu, S. Kamado, K. Oh-ishi, Yun Qin   +4 more
doaj   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

Evolution of Dynamic Recrystallization in 5CrNiMoV Steel during Hot Forming

Advances in Materials Science and Engineering, 2020
The dynamic recrystallization (DRX) behavior of 5CrNiMoV steel was investigated through hot compression at temperatures of 830–1230°C and strain rates of 0.001–10 s−1.
Zhiqiang Hu, Kaikun Wang
doaj   +1 more source

Isolation of Metabolites With Antiviral Activity From the Brown Algae Dictyota fasciola and Dictyota mediterranea

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Twenty‐one compounds, including six dolabellanes diterpenes and one germacrene sesquiterpene that are new natural products, are reported from the brown algae Dictyota fasciola and Dictyota mediterranea collected from the Aegean Sea. Among them, some exhibit considerable antiviral activity against RNA (HCoV‐NL63, ZIKV) and DNA (HSV‐1) viruses.
Aikaterini Koutsaviti, Elsi‐Evangelia Andriotaki, Maria Harizani, Katarzyna Owczarek, Magdalena Pachota, Aleksandra Synowiec, Artur Szczepański, Paweł Botwina, Krzysztof Pyrć, Vassilios Roussis, Efstathia Ioannou   +10 more
wiley   +1 more source

A Modular, Accessible, and Low‐Cost Photoreactor with Precision Light and Temperature Control for Small‐Scale Reactions

Chemistry–Methods, Volume 6, Issue 6, June 2026.
This modular, low‐cost, light‐emitting diode (LED)‐based photoreactor facilitates modulation of light intensity, choice of wavelength, and thermal equilibration for photochemical reactions at a small scale with the potential to normalize research outputs across different laboratories.
Irma G. Vermeijlen, Will Anderson, Gayathri R. Ediriweera, Nicholas L. Fletcher, Craig A. Bell, Kristofer J. Thurecht   +5 more
wiley   +1 more source