Results 61 to 70 of about 14,252 (257)
Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design
Advanced Healthcare Materials, EarlyView.Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan +11 morewiley +1 more sourceRegular treatment with formoterol for chronic asthma: serious adverse events [PDF]
, 2012 Epidemiological evidence has suggested a link between beta(2)-agonists and increases in asthma mortality. There has been much debate about possible causal links for this association, and whether regular (daily) long-acting beta2-agonists are safe ...Altman, Blauw, Cates, Cates, Cates, Cates, Ducharme, Greenstone, Higgins, Lipworth, Nelson, Ni Chroinin, Ni Chroinin, Pearce, Pearce, Salpeter, Walters, Walters +17 morecore +1 more sourceHybrid Nanofibers for Multimodal Accelerated Wound Healing
Advanced Healthcare Materials, EarlyView.Fabrication of wound healing scaffolds based on biocompatible nanofibers. Nanofibers offering high surface area, flexibility, and biocompatibility significantly improved the healing outcome in vivo. Histological, immunological, and anti‐inflammatory markers are noticeably better in treated wounds.Viraj P. Nirwan, Bence Bajusz, Norbert Fabók, Marina Rudan Dimlic, Jelena Budimir, Tshepang Mqatywa, Miklós Gyöngy, Márton Ferencz, Dorottya Kocsis, Olexandr Bondarenko, Mariia Rolduhina, Milena Lengyel, Istvan Antal, Rebecca Hengsbach, Franciska Erdő, Amir Fahmi +15 morewiley +1 more sourceParticle engineering in dry powders for inhalation
European Journal of Pharmaceutical Sciences, 2022 Drug administration by inhalation is a well-established approach to treat respiratory and systemic diseases. To deliver a drug into the lung dry powder inhalation (DPI) is an advantageous, but yet challenging option. A variety of strategies is available for developing DPI formulations.Regina Scherließ, Simon Bock, Nicholas Bungert, Anna Neustock, Lena Valentin +4 moreopenaire +2 more sourcesLong-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis. [PDF]
, 2014 BACKGROUND: Pharmacological therapy for chronic obstructive pulmonary disease (COPD) is aimed at relieving symptoms, improving quality of life and preventing or treating exacerbations.Treatment tends to begin with one inhaler, and additional therapies ...Aalbers, Abrahams, Abrahams, Adams, Agusti, Allegra, Ambrosino, Amgott, Anderson, Anonymous, Anthonisen, Antoniu, Anzueto, Anzueto, Appleton, Arievich, Auffarth, Bale, Barnes, Barnes, Barnes, Barr, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Baumgartner, Beeh, Beeh, Beeh, Berger, Bleecker, Bleecker, Bleecker, Bogdan, Bogdan, Bourbeau, Bourbeau, Braido, Briggs, Briggs, Briggs, Briggs, Brightling, Brusasco, Brusasco, Buhl, Buhl, Burge, Burge, Burge, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley PMA (on behalf of the Symbicort® study group), Calverly, Calverly, Campbell, Campbell, Casaburi, Cazzola, Cazzola, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Chan, Chapman, Chavannes, Chavannes, Chavannes, Chong, Choudhury, Chuck, Cipriani, Claverley, Cooper, Cooper, Cooper, Cooper, Cope, Cope, Corhay, Corhay, Covelli, Crim, Culpitt, D'Amato, D'Urzo, D'Urzo, D'Urzo, D'Urzo, D'Urzo, D'Urzo, Dahl, Dahl, Dahl, Dahl, Dahl, Dahl, Dahl, Dal Negro, Dal Negro, Dalal, Dalal, Dawber, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Derenne, Dias, Dias, Dias, DiSantostefano, Doherty, Doherty, Doherty, Doherty, Dong, Donohue, Donohue, Donohue, Donohue, Donohue, Dransfield, Dunn, Dusser, Dusser, Dusser, Earnshaw, Eden, Edin, Effing, Eichenhorn, Fang, Fattore, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferreira, Freeman, Freeman, Friedman, Frith, Fukuchi, Fukuchi, Geake, Gelb, Gizycki, Glaab, Greefhorst, Greefhorst, Greefhorst, Gross, Grunsven, Grunsven, Guenette, Halpin, Halpin, Halpin, Hanania, Hanania, Hanania, Hanania, Hanrahan, Hanrahan, Hanrahan, Hanrahan, Hanrahan, Hattotuwa, Hettle, Hodder, Hogan, Hoogendoorn, Horstman, Houghton, Hunjan, Hunjan, Hutchinson, Inoue, Janssens, Jarad, Jenkins, Jenkins, Johansson, John, Johnell, Johnson, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Kaptein, Kardos, Kardos, Karner, Karner, Karner, Karner, Kato, Keene, Kerstjens, Kerstjens, Kerstjens, Kerstjens, Kerstjens, Kerstjens, Kerwin, Kerwin, Kerwin, Kerwin, Kerwin, Kerwin, Kesten, Kesten, Kesten, Kew, Kew, Khamis, Korenblat, Kornmann, Kornmann, Kristufek, Kristufek, Kristufek, Kunz, Lacasse, Langley, Lapperre, Laties, Littner, Llewellyn-Jones, Lofdahl, Lofdahl, Lofdahl, Lofdahl, Loke, Loppow, Lu, Lung Health Study Research Group, Löfdahl, Magnussen, Mahler, Mahler, Mahler, Mahler, Mahler, Mahler, Mahler, Mahler, Mahmud, Martinez, Matiz-Bueno, Matiz-Bueno, McDonough, McGarvey, McGarvey, McGarvey, Meer Regina, Mirici, Moen, Moita, Moita, Morice, Morice, Nannini, Nannini, Nannini, Nelson, Nelson, Nelson, Nelson, Nelson, Niewoehner, Niewoehner, Nishimura, Nitschmann, Noppen, O'Donnell, Ohar, Osztovits, Overbeek, Ozol, Ozol, Paggiaro, Paggiaro, Paggiaro, Paggiaro, Pauwels, Pauwels, Pauwels, Powrie, Powrie, Puhan, Puhan, Qiu, Qiu, Rabe, Renkema, Renkema, Rennard, Rennard, Rennard, Rennard, Rennard, Rennard, Rennard, Rennard, Rice, Rizzato, Robertson, Rodrigo, Rodrigo, Rodriguez Gonzalez-Moro, Rossi, Rutgers, Rutten-van Molken, Rutten-van Molken, Rutten-van Mölken, Rutten-van Mölken, Rutten-van Mölken, Sacchetta, Scanlon, Schermer, Sciurba, Sciurba, Scott, Scott, Seemungal, Seemungal, Senderovitz, Senderovitz, Serby, Sestini, Shaker, Shaker, Sharafkhaneh, Sharafkhaneh, Sharafkhaneh, Sin, Sin, Singh, Singh, Singh, Southard, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spiegelhalter, Stockley, Sun, Szafranski, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Thompson, Thompson, To, Tonnei, Tonnel, Troosters, Troosters, Valk, Verhoeven, Verhoeven, Verhoeven, Verhoeven, Verhoeven, Verkindre, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vogelmeier, Vogelmeier, Vogelmeier, Vogelmeier, Vogelmeier, Vogelmeier, Voshaar, Voshaar, Wadbo, Watkins, Wedzicha, Wedzicha, Wedzicha, Wedzicha, Wedzicha, Weel, Weiner, Weiner, Weir, Weir, Weir, Weir, Welsh, Welte, Welte, Welte, Welte, Welte, Wempe, Wouters, Yan, Yang, Yildiz, Zaniolo, Zheng, Zheng, Zhong, Zhong, Zhong, Zu Wallack, ZuWallack +511 morecore +1 more sourceDual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy
Advanced Healthcare Materials, EarlyView.Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan +12 morewiley +1 more sourceMedical Fabrics with Non‐Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination
Advanced Healthcare Materials, EarlyView.The study presents an antibiotic‐free strategy using medical fabrics coated with supramolecular assemblies of polyarginine and hyaluronic acid. These coatings showed strong antimicrobial and anti‐biofilm activity in vitro and in vivo, achieving major bacterial load reductions, including against MRSA.Adjara Diarrassouba, Abdessalem Rekiki, Cécile Loubière, Sabine Kuchler‐Bopp, Lauriane Petit, Cynthia Calligaro, Derry Mercer, Aurore Gaudin, Naomi Canourgues, Emilie Adicéam, Benoit Beitz, Jeremy Welsch, Annabelle Vigué, Markus j. Kettel, Michael Karl, Chloé Guilbaud‐Chéreau, Philippe Lavalle, Nihal Engin Vrana, Skander Hathroubi +18 morewiley +1 more source
