Results 61 to 70 of about 505,344 (284)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Triple oxygen isotopes indicate urbanization affects sources of nitrate in wet and dry atmospheric deposition [PDF]

Atmospheric Chemistry and Physics, 2018
Atmospheric nitrate deposition resulting from anthropogenic activities negatively affects human and environmental health. Identifying deposited nitrate that is produced locally vs.
D. M. Nelson, D. M. Nelson, U. Tsunogai, D. Ding, T. Ohyama, D. D. Komatsu, D. D. Komatsu, F. Nakagawa, I. Noguchi, T. Yamaguchi   +9 more
doaj   +1 more source

Dry granular flows with erosion/deposition process [PDF]

ESAIM: Proceedings, 2009
In this work we use the erodible model proposed by Tai and Kuo to investigate complex granular ows in which deposition and erosion are signicant. The initial motivation comes from experiments of granular collapse which exhibit both phenomena. A numerical model with a ux balanced scheme is developed, and the eigenstructure of its quasilinear form as ...
Kuo, C.Y., Nkonga, Boniface, Ricchiuto, Mario, Tai, Y.-C., Braconnier, Benjamin   +4 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The contributions of snow, fog, and dry deposition to the summer flux of anions and cations at Summit, Greenland [PDF]

, 1995
Experiments were performed during the period May–July of 1993 at Summit, Greenland. Aerosol mass size distributions as well as daily average concentrations of several anionic and cationic species were measured.
Bergin, M H, Davidson, C, Dibb, Jack E., Hillamo, R, Jaffrezo, J L, Kuhns, H D, Maenhaut, W, Makela, T, Pandis, S N   +8 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Surface and boundary layer exchanges of volatile organic compounds, nitrogen oxides and ozone during the GABRIEL campaign [PDF]

, 2008
We present an evaluation of sources, sinks and turbulent transport of nitrogen oxides, ozone and volatile organic compounds (VOC) in the boundary layer over French Guyana and Suriname during the October 2005 GABRIEL campaign by simulating observations ...
Eerdekens, G., Feig, G., Ganzeveld, L.N., Vilà-Guerau de Arellano, J.   +3 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Atmosphere-forest Exchange of Ammoniacal Nitrogen in a Subalpine Deciduous Forest in Central Japan during a Summer Week

Asian Journal of Atmospheric Environment, 2011
The present study aimed to investigate the diurnal variations in air concentrations and exchange fluxes of ammoniacal nitrogen (NHx: ammonia (NH3) and particulate ammonium) in a subalpine deciduous forest in central Japan during a week in summer. The NH3
Kentaro Hayashi, Kazuhide Matsuda, Akira Takahashi, Ko Nakaya   +3 more
doaj   +1 more source

Redox Control of Particle Deposition from Drying Drops

ACS Applied Materials & Interfaces, 2022
The coffee-ring effect (CRE), which denotes the accumulation of nonvolatile compounds at the periphery of a pinned sessile drying drop, is a universal and ubiquitous yet complex phenomenon. It is crucial to better understand and control it, either to avoid its various deleterious consequences in many processes requiring homogeneous deposition or to ...
Galy, Pauline, Guitton-Spassky, Tiffany, Sella, Catherine, Thouin, Laurent, Vitale, Maxime, Baigl, Damien   +5 more
openaire   +2 more sources