Results 121 to 130 of about 6,747,004 (260)

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Tear osmolarity and dry eye symptoms in diabetics

, 2014
Nicole Fuerst,1 Nicole Langelier,1 Mina Massaro-Giordano,1 Maxwell Pistilli,1 Kalliopi Stasi,1 Carrie Burns,2 Serena Cardillo,2 Vatinee Y Bunya1 1Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;
Bunya VY, Cardillo S, Stasi K, Pistilli M, Fuerst N, Massaro-Giordano M, Burns C, Langelier N   +7 more
core  

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Novel therapeutics for dry eye disease

Annals of Medicine, 2023
Duoduo Wu, Louis Tong, Arun Prasath, Blanche Xiao Hong Lim, Dawn Ka-Ann Lim, Chris Hong Long Lim   +5 more
doaj   +1 more source

Management of Glaucoma-Related Dry Eye Disease with Intense Pulsed Light: A Randomized Control Study [PDF]

Hongda Zhang,1,* Yifan Qi,1,* Jiayan Chen,1 Guanghao Qin,1 Ling Xu,1 Wei He,1 Sile Yu,1,2 Huixin Che,1 Emmanuel Eric Pazo1 1Department of Ophthalmology, He Eye Specialist Hospital, Shenyang, Liaoning, People’s Republic of China; 2School of Public
Xu L, Chen J, Yu S, He W, Zhang H, Qi Y, Che H, Pazo EE, Qin G   +8 more
core  

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Exercise program improved subjective dry eye symptoms for office workers

, 2018
Kokoro Sano,1 Motoko Kawashima,1 Sayuri Takechi,2 Masaru Mimura,2 Kazuo Tsubota1 1Department of Ophthalmology, 2Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Introduction: We investigated the benefits of a cognitive ...
Kawashima M, Sano K, Tsubota K, Takechi S, Mimura M   +4 more
core  

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Moderated mediation model of the association between problematic smartphone use and dry eye disease within Moroccan adolescents

Scientific Reports
This study scrutinizes the mediating role of sleep disturbance in the relationship between problematic smartphone use and dry eye disease and examines the moderating role of physical activity.
Samira Bouazza, Samira Abbouyi, Btissame Zarrouq   +2 more
doaj   +1 more source

Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction

, 2017
Shiro Amano, Kenji Inoue Inouye Eye Hospital, Chiyoda-ku, Tokyo, Japan Purpose: To prospectively evaluate the effect of topical diquafosol sodium on eyes with dry eye disease (DED) and meibomian gland dysfunction (MGD).Patients and methods: The ...
Amano S, Inoue K
core