Results 71 to 80 of about 42,739 (239)

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

Journal of Inflammation, 2017
Primary Sjögren’s syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes.
Kendrick Co Shih, Christie Nicole Lun, Vishal Jhanji, Bernard Yu-Hor Thong, Louis Tong   +4 more
doaj   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Biomechanical Parameters of the Cornea in Patients Who are Candidates for Laser Refractive Surgery with Complex Myopic Astigmatism and Dry Eye Syndrome

Oftalʹmologiâ
Purpose. To analyze the corneal indices obtained during examination with the Corvis® ST device of myopic patients — candidates for laser refractive surgery with dry eye syndrome (DES), before and after its treatment.Patients and methods.
О. A. Klokova, S. N. Sakhnov, A. G. Zabolotniy, M. B. Аliev, A. I. Kacharov   +4 more
doaj   +1 more source

Maternal‐to‐Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines

Clinical Pharmacology &Therapeutics, EarlyView.
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Katherine Richardson, Joshua Kiptoo, Beatrice Mpora Odongkara, Francis Williams Ojara, Catriona Waitt   +4 more
wiley   +1 more source

Myomaker and Myomixer are required for craniofacial myoblast fusion in zebrafish

Developmental Dynamics, EarlyView.
Abstract Background Craniofacial and trunk skeletal muscles are derived from different progenitor populations during development. Trunk skeletal muscles contain mostly multinucleated myofibers that are formed through myoblast fusion. However, myoblast fusion in craniofacial muscles and its molecular regulation are not well understood.
Zhanxiong Zhang, Pengzheng Yong, Qiaomu Hu, Shaojun Du   +3 more
wiley   +1 more source

Features of dry eye syndrome treatment [PDF]

Клиническая офтальмология, 2018
E.A. Egorov Pirogov Russian National Research Medical University, Moscow, Russian Federation Abstract Dry eye syndrome (DES) is a multifactorial disease of eye surface, characterized by a disturbance of tear film homeostasis and accompanied by ...
E.A. Egorov
doaj  

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

Dupilumab‐Related Adverse Events and Intolerance in Aspirin‐Exacerbated Respiratory Disease Patients

International Forum of Allergy &Rhinology, EarlyView.
Lancelot P. Herpin, Randy Bach, Ricardo Bruneto, Kerol A. Faltas, Michael A. Kohanski, James N. Palmer, Nithin D. Adappa, Jennifer E. Douglas, John V. Bosso   +8 more
wiley   +1 more source

Blue‐hazard‐free single‐emissive‐layer white organic LEDs based on an anti‐quenching narrowband blue emitter

FlexMat, EarlyView.
A blue‐hazard‐free single‐emissive‐layer white OLED is realized using an anti‐quenching multiple‐resonance TADF emitter, BNCT. By integrating a sterically protected MR core with efficient energy transfer capability, BNCT enables warm‐white emission with high efficiency, negligible hazardous blue photons, and a simplified device architecture for next ...
Xiao‐Long Liu, Wei‐Le Wu, Ru‐Jia Wang, Xin‐Lu Li, Jia‐Ming Jin, Ji‐Hua Tan, Hong‐Ji Tan, Yanping Huo, Hao‐Li Zhang, Wen‐Cheng Chen   +9 more
wiley   +1 more source

A case with acquired lacrimal fistula due to Sjögren's syndrome

American Journal of Ophthalmology Case Reports, 2019
Purpose: To report a case with lacrimal fistula presumably associated with Sjögren's syndrome. Observations: A patient with Sjögren's syndrome was referred to our hospital for fistula from the inferior lacrimal canaliculus to the palpebral conjunctiva of
Sho Ishikawa, Takuhei Shoji, Yuri Nishiyama, Kei Shinoda   +3 more
doaj   +1 more source