Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele +7 more
wiley +1 more source
Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy. [PDF]
Machane D +3 more
europepmc +1 more source
Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi +2 more
wiley +1 more source
Potential role of the ocular surface microbiome in dry eye: microbial interactions and symptom alleviation. [PDF]
Park J-Y +4 more
europepmc +1 more source
Role of Orbicularis Oculi Resection in External Levator Advancement for Aponeurotic Blepharoptosis: A Prospective Randomised Controlled Trial. [PDF]
Rojanasakul S, Putthirangsiwong B.
europepmc +1 more source
Prevalence and Risk Factors of Computer Vision Syndrome Among Bankers in Bangladesh
This graphical abstract illustrates the prevalence of computer vision syndrome and its associated demographic, occupational, and environmental risk factors among bank employees in Bangladesh. ABSTRACT Background The increasing reliance on digital devices in modern workplaces has raised significant concerns about computer vision syndrome (CVS ...
Bodrunnahar Barna +4 more
wiley +1 more source
A Droplet Evaporimeter for Evaluating Eye Care Formulations. [PDF]
Peng CC +5 more
europepmc +1 more source
Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024)
ABSTRACT Obstructive sleep apnea (OSA) is a common chronic disorder characterized by abnormal breathing during sleeping. OSA can damage various organs throughout the body and is burdensome, both socially and economically. Moreover, as OSA has been increasingly studied in recent years, new evidence‐based guidelines for its diagnosis and surgical ...
Working Group of Guideline for the Diagnosis and Surgical Treatment of Adult OSA +7 more
wiley +1 more source
Association Between Sleep Apnea and Dry Eye Disease in the All-of-Us Program. [PDF]
Zhang A, He J, Ying GS.
europepmc +1 more source
Outcome parameters in studies investigating dry eye disease: A systematic literature review
Abstract The development of effective therapeutics for dry eye disease (DED) is challenging due to its complex pathophysiology, heterogeneous patient presentation and the significant failure rate of previous clinical development programs. This underlines the importance of the selection of appropriate endpoints for clinical trials.
Viktoria Pai +8 more
wiley +1 more source

