Results 281 to 290 of about 108,243 (386)

A Proof‐of‐Concept Phase 2a Partly Randomised Study Evaluating Leronlimab in Patients With Presumed Non‐Cirrhotic Metabolic Dysfunction–Associated Steatohepatitis

Liver International Communications, Volume 6, Issue 4, December 2025.
ABSTRACT Chemokine receptor type 5 (CCR5) is upregulated in the livers of patients with metabolic dysfunction–associated steatohepatitis (MASH). Leronlimab, a humanised IgG4κ monoclonal antibody, directly binds the extracellular domains of CCR5, modulates downstream signalling and potentially can slow, reverse or prevent fibrosis. The aim of this study
Melissa Palmer, A. Cyrus Arman, Eric J. Lawitz, William E. Sanchez, Shilpi Mittal, Tarek Hassanein, Scott G. Hansen, Joseph Meidling, Bernie Cunningham, Neil E. Buss, Jacob P. Lalezari   +10 more
wiley   +1 more source

The relation between corneal optical quality and clinical ocular surface manifestations in Chinese female with Sjogren's syndrome dry eye. [PDF]

BMC Ophthalmol
Zhang J, Deng Q, Maitiyaer M, Wang L, Huang AM, Liang Y, Huang Q, Yu S, Liu Z.   +8 more
europepmc   +1 more source

Prevention and treatment of degenerative changes in ocular surface epithelium in patients with dry eye syndrome

, 2018
V.V. Brzheskiy, V.Yu. Popov, Н. М. Калинина, I. V. Brzheskaya   +3 more
openalex   +1 more source

Vitamin‐Engineered Nanoplatforms in Precision Oncology: Integrating Immunotherapy, Delivery Systems, and Theranostics

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Vitamin‐derived nanoplatforms advance precision oncology by augmenting immunotherapy through dendritic cell activation, T‐cell reprogramming, and TME remodeling to enhance antitumor immunity, while enabling targeted therapeutic delivery. These systems integrate theranostic capabilities using vitamin‐conjugated imaging probes for concurrent tumor ...
Ruowa Xu, Yunlong Gao, Hailong Zhang, Zichao Luo   +3 more
wiley   +1 more source

Safety and Efficacy of Diquafosol Compared to Artificial Tears for the Treatment of Dry Eye: A Systematic Review and Meta-Analysis. [PDF]

Int J Mol Sci
Serrano-Robles JG, Pérez-Vázquez AK, Vera-Duarte GR, Navas A, Ramirez-Miranda A, Graue-Hernandez EO, Kahuam-López N.   +6 more
europepmc   +1 more source

Aryl Hydrocarbon Receptor in Health and Disease

MedComm, Volume 6, Issue 11, November 2025.
Based on the structure and ligands of AhR, this review introduces the AhR‐related signaling pathways and their roles in health and diseases. Agonists and antagonists of AhR as well as new strategies for treatment using the microbial–AhR axis are summarized. A prospect was made for the future use of AhR as a therapeutic target.
Haonan Li, Yufeng Fan, Jizheng Liu, Shumin Dong, Bin Wen, Yunfei Zhang, Xiaocui Wang, Xuemei Duan, Ying Hu, Ze Yan, Huifeng Shang, Yukai Jing   +11 more
wiley   +1 more source

Topical lifitegrast therapy for dry eye disease. [PDF]

Cochrane Database Syst Rev
Assi L, Lutfallah SC, Yim TW, Liu SH, Duffy SJ, Weiss J.   +5 more
europepmc   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Evaluation of the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women. [PDF]

Sci Rep
Li T, Tang J, Wang X, Lin Z, Li C, Liu G, Xiao G.   +6 more
europepmc   +1 more source

Preservatives in artificial tears: Assessing impact on dry eye symptoms

Acta Ophthalmologica, Volume 103, Issue 7, Page 823-830, November 2025.
Abstract Purpose To examine the association between the presence of dry eye disease (DED) symptoms when using BAK‐preserved artificial tears (AT) compared to preservative‐free AT. Methods In this cross‐sectional study, we used data collected as part of Project ‘Finding Ophthalmic Risk and Evaluating the Value of Eye exams and their predictive ...
Astrid Dissing Sjö, Jens Rovelt, Simone Ahrenberg, Miriam Kolko   +3 more
wiley   +1 more source