Results 31 to 40 of about 1,645,367 (305)

Treatment of Ocular Pain Not Responsive to Traditional Dry Eye Disease Treatments

, 2023
Neuropathic ocular pain (NOP) in dry eye disease can be a challenging condition to treat. The pathogenesis of NOP often results from injury to the corneal nerves, leading to neural plasticity and peripheral and central neuronal sensitization.
Kuruvilla, Merin, Sarantopoulos, Konstantinos D., Kalangara, Jerry, Konstantinos D. Sarantopoulos, Jerry Kalangara, Merin Kuruvilla   +5 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Cost utility analysis of cryopreserved amniotic membrane versus topical cyclosporine for the treatment of moderate to severe dry eye syndrome

Cost Effectiveness and Resource Allocation, 2020
Background The purpose is to perform a cost effectiveness analysis amniotic membrane vs. topical medications in the use of treating dry eye disease.
Jeffrey Voigt
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Exploring the impact of Islamic prayer (‘salat’) on tear film parameters: An observational study

Journal of the Pakistan Medical Association
Objective: To explore the impact of ‘salat’ on the comfort, stability, and quality of tear film. Method: The observational, comparative study was conducted in June 2024 at the College of Applied Medical Sciences in Riyadh, Saudi Arabia, and included ...
Meznah Saud Almutairi, Azizah Alshaibani, Basal Hamad Altoaimi, Gamal Abdel-Rahman El-Hiti   +3 more
doaj   +1 more source

Meibomian Gland Dropout in Patients with Dry Eye Disease in China

, 2014
Purpose: To examine the morphological changes in the meibomian glands of eyes of patients with dry eye disease using the non-contact infrared meibography system and to assess their relationship with meibomian dropout, signs, and tear-film function ...
Gao, Ziqing, Qu, Hongqiang, Feng, Kang, Hong, Jing, Feng, Yun   +4 more
core   +1 more source

Current Management and Treatment of Dry Eye Disease [PDF]

, 2018
A better understanding of the pathophysiology and etiology of dry eye disease leads to more efficient management and treatment of the disease process.
Cem Şimşek, Kazuo Tsubota, Murat Doğru, Takashi Kojima   +3 more
core   +1 more source

Adaptive Conductive Systems: Enabling Deformable Electronics Through Engineered Materials, Circuits, and Intelligent Systems

Advanced Science, EarlyView.
This review presents the research advances of adaptive conductive systems from the perspective of materials, circuits, systems, and applications. Deformable conductors consist of substrates/matrices and conductive materials, structural design of circuit interconnections, fabrication of circuit interconnections, as well as intelligent systems ...
Yufei Lu, Siyu Liang, Jingyi Niu, Jie Chen, Shuo Zhang, Hongjian Zhang, Dongsheng Jia, Wei Huang   +7 more
wiley   +1 more source

Dry Eye Syndrome in Intensive Care Units: a concept analysis

Revista Brasileira de Enfermagem
Purpose: To analyse the concept of Dry Eye Syndrome in patients admitted to Intensive Care Units (ICU). Method: This is a concept analysis, according to Walker’s and Avant’s method, conducted using an integrative review, through search in the database ...
Ana Paula Nunes de Lima Fernandes, Jessica Naiara de Medeiros Araújo, Fabiane Rocha Botarelli, Danielly Oliveira Pitombeira, Marcos Antonio Ferreira Júnior, Allyne Fortes Vitor   +5 more
doaj   +1 more source