Results 61 to 70 of about 9,199 (313)
Simulating the Heat Distortiion of a Cast Iron Brake Disc during Dry Machining [PDF]
, 2012 The application of MQL or dry machining in mass production becomes more and more accepted. Dry (MQL) machining is a very efficient solution to reduce the usage of cutting fluids and represents an effective measure for an environmental friendly production.
KOPPKA, Frank +5 more
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Dry cutting: a sustainable machining technology
, 2021 Conventional cutting fluids with flood cooling are used to reduce the heat generation during machining but at the cost of environmental degradation. The hydrocarbon-based conventional cutting fluids are harmful to the operator’s health, environmentally ...
Bayraktar, Şenol, Senol Bayraktar
core +1 more source
Engineering ProceedingsMachining is a fundamental manufacturing process that entails the controlled removal of material from a workpiece to achieve desired shapes and dimensions.
Shailendra Pawanr, Kapil Gupta
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Dry Ice in the Machine Shop [PDF]
Nature, 1934 IN the issue of NATURE of October 6, on page 529, mention is made of the use of dry ice in the machine shop.
openaire +2 more sources
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Identification of the heat input during dry or MQL machining [PDF]
, 2012 Machining with minimum quantity lubrication (MQL) has been the focus of many scientific investigations since the last 20 years. Nevertheless an acceptable method of predicting the thermal influences on the workpiece quality has still not been developed ...
KOPPKA, Frank +3 more
core