Results 71 to 80 of about 4,231,544 (295)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Biostimulators as a factor affecting the dry matter yield and starch content of edible potato tubers [PDF]

, 2019
The experiment was carried out as a two-factor experiment in a split-plot system, repeated three times within the years 2015-2017 on an individual farm.
Mystkowska, I.T.
core   +1 more source

Suppressive effects on weeds and dry matter yields of cover crops [PDF]

Pesquisa Agropecuária Brasileira, 2018
Abstract: The objective of this work was to evaluate the dry matter yield of cover crops and their suppressive effects on weeds. The experiment was carried out during three years in a cerrado area of the state of Goiás, Brazil, and consisted of 16 treatments with fallow and cover crops cultivated in single cropping and intercropping.
Ferreira, Alexandre Cunha de Barcellos, Borin, Ana Luiza Dias Coelho, Bogiani, Julio Cesar, Lamas, Fernando Mendes   +3 more
openaire   +4 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Genetic variability and association studies in guar [Cyamopsis tetragonoloba (L.) Taub.) for green fodder yield and quality traits [PDF]

Electronic Journal of Plant Breeding, 2014
Seventy six clusterbean [Cyamopsis tetragonoloba (L.) Taub.) genotypes were analysed for genetic variability, correlation and path coefficients. The genotypes were significantly different for all the characters, which indicated scope for further genetic ...
Rahul Kapoor
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Relationships between buffalo milk components and curd characteristics

Italian Journal of Animal Science, 2010
The aim of this study was to evaluate the coefficients of correlation between curd chemical composition and milk characteristics, theoretical and real cheese yield and ratios between cheese yield and protein percentage. The analysis were performed on 326
F. Zicarelli, R. Di Palo, G. Campanile, C. Caso, G. Fusco, R. Napolano, A. Potena   +6 more
doaj   +1 more source

The influence of extraction and precipitation pH on the dry matter yield of broiler dark meat

Poultry Science, 2005
In recent years, demand for white meat products has resulted in excess supplies and depressed prices of leg meat in the United States. One approach to increasing the utilization of dark meat is to extract the pigments and fat to make the resulting product more acceptable for the production of further-processed meat products.
BETTI, MIRKO, D. L. Fletcher
openaire   +4 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Yield trends and yield gap analysis of major crops in the world [PDF]

, 2009
This study aims to quantify the gap between current and potential yields of major crops in the world, and the production constraints that contribute to this yield gap. Using an expert-based evaluation of yield gaps and the literature, global and regional
Hengsdijk, H., Langeveld, J.W.A.
core