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Dry powder inhalation, part 2
Expert Opinion on Drug Delivery, 2022 Introduction: The manufacture of modern dry powder inhalers (DPIs), starting with the Spinhaler (Fisons) in 1967, was only possible thanks to a series of technological developments in the 20th century, of which many started first around 1950. Not until then, it became possible to design and develop effective, cheap and mass-produced DPIs.de Boer, Anne Haaije, Hagedoorn, Paul, Grasmeijer, Floris +2 moreopenaire +1 more sourceThe crucial role of leucine concentration on spray dried mannitol-leucine as a single carrier to enhance the aerosolization performance of Albuterol sulfate [PDF]
, 2018 Generally, DPI formulations show low fine particle fraction (FPF) due to poor detachment of drug particles from carrier during inhalation. L-Leucine, with varying concentrations (ranging from 0 to 10% w/w), were introduced into a 60%w/v mannitol solution Adia, Aquino, Boraey, Brannan, Budavari, Bugay, Burger, Chan, Daviskas, Daviskas, Daviskas, De Boer, De Boer, Debord, Decimo, Feng, Healy, Heyder, Hickey, Jaques, Jones, Jones, Kaialy, Kaialy, Kaialy, Kaialy, King, Labiris, Le, Malcolmson, Mansour, Mizoe, Molina, Mondragon, Saint-Lorant, Shoyele, Smyth, Sou, Staniforth, Staniforth, Vehring, Wills, Yoshinari +42 morecore +2 more sourcesADVANCEMENTS IN DRY POWDER INHALER
Asian Journal of Pharmaceutical and Clinical Research, 2017 The dry powder inhaler (DPI) has become widely known as a very attractive platform for drug delivery. DPIs are being used for the treatment of asthma and chronic obstructive pulmonary disease by many patients. There are over 20 devices presently in the DPI market. DPIs are preferred over nebulizers and pressurized metered dose inhalers.Ganga Srinivasan, Advait Shettyopenaire +2 more sourcesLong-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis. [PDF]
, 2014 BACKGROUND: Pharmacological therapy for chronic obstructive pulmonary disease (COPD) is aimed at relieving symptoms, improving quality of life and preventing or treating exacerbations.Treatment tends to begin with one inhaler, and additional therapies ...Aalbers, Abrahams, Abrahams, Adams, Agusti, Allegra, Ambrosino, Amgott, Anderson, Anonymous, Anthonisen, Antoniu, Anzueto, Anzueto, Appleton, Arievich, Auffarth, Bale, Barnes, Barnes, Barnes, Barr, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Baumgartner, Beeh, Beeh, Beeh, Berger, Bleecker, Bleecker, Bleecker, Bogdan, Bogdan, Bourbeau, Bourbeau, Braido, Briggs, Briggs, Briggs, Briggs, Brightling, Brusasco, Brusasco, Buhl, Buhl, Burge, Burge, Burge, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley PMA (on behalf of the Symbicort® study group), Calverly, Calverly, Campbell, Campbell, Casaburi, Cazzola, Cazzola, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Celli, Chan, Chapman, Chavannes, Chavannes, Chavannes, Chong, Choudhury, Chuck, Cipriani, Claverley, Cooper, Cooper, Cooper, Cooper, Cope, Cope, Corhay, Corhay, Covelli, Crim, Culpitt, D'Amato, D'Urzo, D'Urzo, D'Urzo, D'Urzo, D'Urzo, D'Urzo, Dahl, Dahl, Dahl, Dahl, Dahl, Dahl, Dahl, Dal Negro, Dal Negro, Dalal, Dalal, Dawber, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Decramer, Derenne, Dias, Dias, Dias, DiSantostefano, Doherty, Doherty, Doherty, Doherty, Dong, Donohue, Donohue, Donohue, Donohue, Donohue, Dransfield, Dunn, Dusser, Dusser, Dusser, Earnshaw, Eden, Edin, Effing, Eichenhorn, Fang, Fattore, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Ferreira, Freeman, Freeman, Friedman, Frith, Fukuchi, Fukuchi, Geake, Gelb, Gizycki, Glaab, Greefhorst, Greefhorst, Greefhorst, Gross, Grunsven, Grunsven, Guenette, Halpin, Halpin, Halpin, Hanania, Hanania, Hanania, Hanania, Hanrahan, Hanrahan, Hanrahan, Hanrahan, Hanrahan, Hattotuwa, Hettle, Hodder, Hogan, Hoogendoorn, Horstman, Houghton, Hunjan, Hunjan, Hutchinson, Inoue, Janssens, Jarad, Jenkins, Jenkins, Johansson, John, Johnell, Johnson, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Jones, Kaptein, Kardos, Kardos, Karner, Karner, Karner, Karner, Kato, Keene, Kerstjens, Kerstjens, Kerstjens, Kerstjens, Kerstjens, Kerstjens, Kerwin, Kerwin, Kerwin, Kerwin, Kerwin, Kerwin, Kesten, Kesten, Kesten, Kew, Kew, Khamis, Korenblat, Kornmann, Kornmann, Kristufek, Kristufek, Kristufek, Kunz, Lacasse, Langley, Lapperre, Laties, Littner, Llewellyn-Jones, Lofdahl, Lofdahl, Lofdahl, Lofdahl, Loke, Loppow, Lu, Lung Health Study Research Group, Löfdahl, Magnussen, Mahler, Mahler, Mahler, Mahler, Mahler, Mahler, Mahler, Mahler, Mahmud, Martinez, Matiz-Bueno, Matiz-Bueno, McDonough, McGarvey, McGarvey, McGarvey, Meer Regina, Mirici, Moen, Moita, Moita, Morice, Morice, Nannini, Nannini, Nannini, Nelson, Nelson, Nelson, Nelson, Nelson, Niewoehner, Niewoehner, Nishimura, Nitschmann, Noppen, O'Donnell, Ohar, Osztovits, Overbeek, Ozol, Ozol, Paggiaro, Paggiaro, Paggiaro, Paggiaro, Pauwels, Pauwels, Pauwels, Powrie, Powrie, Puhan, Puhan, Qiu, Qiu, Rabe, Renkema, Renkema, Rennard, Rennard, Rennard, Rennard, Rennard, Rennard, Rennard, Rennard, Rice, Rizzato, Robertson, Rodrigo, Rodrigo, Rodriguez Gonzalez-Moro, Rossi, Rutgers, Rutten-van Molken, Rutten-van Molken, Rutten-van Mölken, Rutten-van Mölken, Rutten-van Mölken, Sacchetta, Scanlon, Schermer, Sciurba, Sciurba, Scott, Scott, Seemungal, Seemungal, Senderovitz, Senderovitz, Serby, Sestini, Shaker, Shaker, Sharafkhaneh, Sharafkhaneh, Sharafkhaneh, Sin, Sin, Singh, Singh, Singh, Southard, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spiegelhalter, Stockley, Sun, Szafranski, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Tashkin, Thompson, Thompson, To, Tonnei, Tonnel, Troosters, Troosters, Valk, Verhoeven, Verhoeven, Verhoeven, Verhoeven, Verhoeven, Verkindre, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vogelmeier, Vogelmeier, Vogelmeier, Vogelmeier, Vogelmeier, Vogelmeier, Voshaar, Voshaar, Wadbo, Watkins, Wedzicha, Wedzicha, Wedzicha, Wedzicha, Wedzicha, Weel, Weiner, Weiner, Weir, Weir, Weir, Weir, Welsh, Welte, Welte, Welte, Welte, Welte, Wempe, Wouters, Yan, Yang, Yildiz, Zaniolo, Zheng, Zheng, Zhong, Zhong, Zhong, Zu Wallack, ZuWallack +511 morecore +1 more sourceDoes size really matter:relationship of particle size to lung deposition and exhaled fraction [PDF]
, 2017 We demonstrate that extra-fine particles are not associated with an appreciably higher exhaled fraction, hence explaining their efficacy profile in asthma. Brian Lipworth, De Backer, Gianluigi Poli, Hauber, Jabbal, Kraft, Lipworth, Manoharan, Manoharan, Nicolini, Sunny Jabbal, Usmani, Usmani +12 morecore +2 more sources[New dry powder inhalers].
Pneumonologia i alergologia polska, 2016 The most recently approved DPI's - Ellipta™ and NEXThaler® are the most modern inhalers on the market. Both are flow independent in the physiological range of flows seen in patients with asthma and/or COPD. Both require three actions (open-load -inhaler) for a successful inhalation.Andrzej, Emeryk, Michał, Pirożyńskiopenaire +1 more source
