Results 31 to 40 of about 718,991 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Dry Extraction via Dry Fractionation Process and Functional Properties of Pea Protein [PDF]
Shipin KexueIn this study, with the aim of pursuing environmental friendliness and maintaining the natural structure of pea protein, dry fractionation of pea protein was conducted by milling and subsequent air classification, yielding fine protein-rich fractions ...
HE Yalin, DENG Yang, LIU Yanfeng, LIU Xiao
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Civil and Environmental EngineeringHot weather conditions increase the thermal conductivity of asphalt pavements, causing heat-related damages. Reducing thermal accumulation in pavement structures is essential to improve durability and service life.
Ibraheem Hassan I., Al-Mmosawe Hasan
doaj +1 more source
Dry Bio-Decontamination Process in Reduced-Pressure O2 Plasma
Applied Sciences, 2019 The main objective of this work was to fully understand the bio-decontamination process in a reduced-pressure oxygen plasma. Gram-negative Escherichia coli species was chosen as the target microorganism in this test.
Hongxia Liu +4 more
doaj +1 more source
Surface integrity evaluation within dry grinding process on automotive gears
Cleaner Engineering and Technology, 2022 Gears are essential components in automotive transmissions and their performance directly depends on the flanks surface integrity. To date the gears whole production chain do not use lubricants, except the final step of finishing which adopts a huge ...
Flavia Lerra +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
International Islamic University Malaysia Engineering JournalRecently, many techniques have been developed to improve the properties of asphalt pavement and to reduce environmental pressure. Adding waste polypropylene (WPP) to asphalt mixtures is one of the most often used and effective techniques.
Israa Daryul, Roaa Latief
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source