Results 91 to 100 of about 258,865 (310)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Study on Seismic Response of Spent Fuel Dry Storage Facility [PDF]

, 2007
用過核子燃料之處理，對核能電廠之營運相當重要。目前在台灣，核能一廠內供短期貯存之燃料池空間即將不足，而供長期存放的最終處置場又尚未確定，故實有必要興建供中期貯存之乾式貯存設施。由於乾式貯存設施多屬自立式結構，在地震發生時，可能會產生滑動或傾覆等穩定性問題，因此，本研究針對將設在核能一廠內之用過核燃料乾式貯存設施，分析其受地震作用時之動態反應。 乾式貯存設施包含座落於土層上之基礎版，以及置放於基礎版上之貯存護箱。對於其受震反應，前人所採之分析法大致有兩種：一為耦合模型，亦即建立護箱~基礎版 ...
Tsao, Shuo-Hsiu, 曹碩修
core  

Applications of dry chain technology to maintain high seed viability in tropical climates [PDF]

PeerJ
Seed storage life in tropical areas is shortened by high humidity and temperature and the general inaccessibility to dehumidifying and refrigeration systems, resulting in rapid decreases in seed viability in storage as well as a high incidence of fungal ...
Filippo Guzzon, Denise E. Costich, Irfan Afzal, Luis Barboza Barquero, Andrés Antonio Monge Vargas, Ester Vargas Ramírez, Pedro Bello, Peetambar Dahal, César Sánchez Cano, Cristian Zavala Espinosa, Shakeel Imran, Soane Patolo, Tevita Ngaloafe Tukia, Johan Van Asbrouck, Elina Nabubuniyaka-Young, Maraeva Gianella, Kent J. Bradford   +16 more
doaj   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

MAKING THE CASE FOR SAFE STORAGE OF USED NUCLEAR FUEL FOR EXTENDED PERIODS OF TIME: COMBINING NEAR-TERM EXPERIMENTS AND ANALYSES WITH LONGER-TERM CONFIRMATORY DEMONSTRATIONS

Nuclear Engineering and Technology, 2013
The need for extended storage of used nuclear fuel is increasing globally as disposition schedules for used fuel are pushed further into the future.
KEN B. SORENSON, BRADY HANSON
doaj   +1 more source

Changes of Rice Storage Proteins Affected by Dry and Storage Temperature

Korean Journal of Environmental Agriculture, 2008
ABSTRACT: Quality of rice grain changes during dry storage with internal physiological changes andexternal injury by organism. Storage rice changes by condition with respiration via variable temperature,hydrolysis enzyme reaction, lipid peroxidation occurs with change of palatability.
Pyung-Gyun Shin, An-Cheol Chang, Seong-Chang Hong, Ki-Sang Lee, Keum-Hee Lee, Yong-Bok Lee   +5 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Critical Thermal Safety Technologies of Spent Fuel Dry Storage Cask [PDF]

, 2017
The decay heat removal analysis is considered as one of the four items of dry storage system safety analysis in addition to criticality analysis, confinement analyses and radiation protection analysis. This paper has illustrated the related standards and
Chu-Yang Yu, Xiao-Ying Qi, Qiong-Hui Tang, Xue-Ling Zhang   +3 more
core   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Comparison of peristrophic multiplexing and a combination of angular and peristrophic holographic multiplexing in a thick PVA/acrylamide photopolymer for data storage [PDF]

, 2007
Two different types of multiplexing are used to store 90 holograms at the same location in a polyvinyl alcoholacrylamide photopolymer material. In the first, the 90 holograms are stored using only peristrophic multiplexing, whereas in the second a ...
Ortuño, Manuel, Gallego, Sergi, Beléndez, Augusto, García Llopis, Celia, Fernandez-Varo, Helena, Pascual, Inmaculada   +5 more
core   +1 more source